I loved protopic at first it would clear or noticably reduce patches overnight. I must have used it for about 2 years on my face as sparingly as possible as said above its strong stuff to be putting on your face.
After about 2 years of using it, I did notice how much it had thinned my skin and my skin had became very photosensitive. Luckily I had a few weeks of UVB which cleared my P completely for a while but once it came back I decided not to go back to Protopic.
As well as those symptoms it would only take a brief change in temperature and my forehead where I was applying it would feel hot and sweaty and feel like it was burning especially right after applying it.
Since my P came back I have been using Emovate on my face, for about a year now and I dont have any ill side effects yet besides I cannot stop using it, the patch's don't go it just keeps them at bay, however this was the same with Protopic for me as well.
I wont use Protopic again personally but what works for one doesn't for another we all react differently.