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BillyTheKid

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Another look at Chinese medicine
« on: May 19, 2005, 09:34:12 PM »
The Treatment of Psoriasis by Clearing Heat & Quickening the Blood

abstracted & translated by

Bob Flaws, Dipl. Ac. & C.H., Lic. Ac., FNAAOM, FRCHM

Keywords: Chinese medicine, Chinese herbal medicine, dermatology, psoriasis

Psoriasis is a commonly seen chronic dermatological condition which is characterized by red macules, silver scales, and itching. Patients usually present with a red or dark red tongue and/or static macules. In Chinese medicine, this presentation is differentiated as blood heat and blood stasis. In issue #2, 2003 of the Bei Jing Zhong Yi Za Zhi (Beijing Journal of Chinese Medicine), Lian Chun-feng of the Dermatology Department of the Tai Cang Municipal Chinese Medicine Hopsital in Jiangsu published an article titled, "A Study of the Treatment Effects of Qing Re Huo Xue Tang (Clear Heat & Quicken the Blood Decoction) on Common Psoriasis." This article appeared on pages 28 and 29 of that journal and a summary is given below.

Cohort description:

Sixty-three patients with common psoriasis seen as out-patients in the Dermatology Department of the author’s hospital were enrolled in this study. Thirty-three of these patients were randomly assigned to the treatment group and 30 were assigned to the comparison group. The members of these two groups were statistically comparable in terms of sex, age, disease duration, the form of their skin lesions, and their Chinese medical pattern discrimination. All these patients had received previous treatment for this condition, including Chinese medicinals and Western pharmaceuticals, without marked effect.


BillyTheKid

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Re: Another look at Chinese medicine
« Reply #1 on: May 19, 2005, 09:35:39 PM »
Treatment method:

Members of the treatment group received a Chinese medicinal formula (of unspecified dosages) of the following medicinals: uncooked Flos Immaturus Sophorae Japonicae ( Huai Hua Mi), Herba Taraxaci Mongolici Cum Radice (Pu Gong Ying), Radix Angelicae Sinensis (Dang Gui), Rhizoma Sparganii Stoloniferii (San Leng), Rhizoma Curcumae Zedoariae (E Zhu), Caulis Milletiae Seu Spatholobi (Ji Xue Teng), Caulis Sargentodoxae (Hong Teng), Herba Oldenlandiae Diffusae Cum Radice (Bai Hua She She Cao), and Radix Et Rhizoma Rhei (Da Huang). One packet of these medicinals was decocted in water and administered in two divided doses per day, with one continuous month of administration equaling one course of treatment. Members of the comparison group received six grams three times per day of the ready-made medicine Qing Dai Wan (Indigo Pills). This medicine only clears heat. Similarly, one continuous month of administration of this medicine equaled one course of treatment for this group. Treatment outcomes were assessed for the members of both groups after two whole courses of treatment. During this treatment, patients were instructed not to use any other internally administered or externally applied medications for this disease. However, all patients in both group did take 25,000u of vitamin A three times per day. If itching was severe, patients were allowed to apply camphor tincture or Niao Su Shuang Zhi Yang Run Zao Ji (Urea Frost Stop Itch & Moisten Dryness Prescription) externally.

Treatment outcomes:

Cure was defined as disappearance of more than 95% of the lesions. Marked effect was defined as disappearance of 70% or more of the lesions. Some effect meant that 25% or more of the lesions disappeared, and no effect meant that less than 25% of the lesions disappeared. Based on these criteria, in the treatment group, nine out of 33 patients were cured, 11 got a marked effect, nine got some effect, and four got no effect, for a total effectiveness rate of 87.9%. In the comparison group, five out of 30 patients were cured, nine got a marked effect, six got some effect, and 10 got no effect, for a total effectiveness rate of 66.7%. Therefore, Qing Re Huo Xue Tang was markedly more effective for the treatment of this condition than Qing Dai Wan (P + 0.05). As for side effects, in the treatment group, some of the patients had diarrhea, one of the females developed profuse menstruation, and one of the patients developed abdominal discomfort after each dose of medicinals. In the comparison group, all the patients developed diarrhea when they began taking the medicine. As treatment continued, this resolved in all cases. However, some of the patients continued to have gastrointestinal tract reactions. One case developed digestive tract bleeding after taking the medicine for two months.

Discussion:

According to Dr. Lian, the onset of psoriasis is related to the blood. This is because the basic disease mechanisms of psoriasis are blood heat, blood stasis, and blood vacuity. In the initial stage, most patients present a pattern of blood heat. However, over time, blood heat boils and cooks the blood to produce blood stasis. Although Dr. Lian does not say so, static blood then hinders the engenderment of new or fresh blood. Therefore, Dr. Lian believes that the main treatment principles for this condition are based on the statement, "For heat, clear it; for stasis, move it." Based on these principles, Qing Re Huo Xue Tang clears heat and cools the blood, quickens the blood and transforms stasis. It also nourishes the blood. Within this formula, Huai Hua Mi, Pu Gong Ying, Hong Teng, Bai Hua She She Cao, and Da Huang clear heat. Dang Gui, San Leng, E Zhu, Hong Teng, Ji Xue Teng, and Da Huang quicken the blood, and Dang Gui and Ji Xue Teng nourish the blood. Dr. Lian believes that the difference in efficacy between the two protocols studied has to do with Qing Dai Wan only clearing heat, while Qing Re Huo Xue Tang clears heat and quickens and nourishes the blood.

Copyright © Blue Poppy Press, 2003. All rights reserved.

For more information on the Chinese medical treatment of psoriasis, see Liang Jian-hui’s Handbook of Traditional Chinese Dermatology available from Blue Poppy Press.

BillyTheKid

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Re: Another look at Chinese medicine
« Reply #2 on: May 19, 2005, 09:37:52 PM »
Psoriasis

abstracted & translated by

Robert Helmer, D.TCM (Canada)

Keywords: Chinese medicine, Chinese herbal medicine, dermatology, psoriasis

In issue #12, 1994 of the Liao Ning Zhong Yi Za Zhi (Liaoning Journal of Chinese Medicine), Zhou Chong-he and Tong Ren-bin published an article titled, "The Treatment of Common Psoriasis with Yin Xie Fang (Psoriasis Formula)." This article appeared on page 559 of that journal. Since sporiasis is often such a difficult condition to treat, a summary is given below.

Cohort description:

Of the 53 cases included in this study, 24 patients were female and 29 were male. Three cases were less than 15 years old, 39 cases were between 15-40 years of age, and 11 cases were more than 40 years of age. The youngest patient was nine years old, and the oldest was 61 years old.  The length of disease was as short as 18 days and as long as 21 years. Among these patients, 41 cases had acute psoriasis, and 12 cases were of a chronic nature. Nine cases had a family history of this disease, and 29 cases developed this disease after contracting a common cold, sore throat, and/or tonsillitis. Of the 12 cases with chronic psoriasis, in nine cases, the skin was worse in the winter and, in the summer, the skin was better. In the other three cases, the seasons did not seem to effect the condition.

Treatment method:

Yin Xie Fang (Psoriasis Formula) consisted of: uncooked Huai Hua (Flos Immaturus Sophorae Japonicae), Tu Fu Ling (Rhizoma Smilacis Galbrae), Bai Xian Pi (Cortex Radicis Dictamni Dasycarpi), and Ji Xue Teng (Caulis Milletiae Seu Spatholobi), 20g each, Dan Shen (Radix Salviae Miltiorrhizae) and Shi Da Po (Herba Chrysotrichae Hedyotis), 10g each, Chi Shao (Radix Rubrus Paeoniae Lactiflorae), 15g, and Gan Cao (Radix Glycyrrhizae Uralensis), 3g.  

Additions: During the acute stage, Sheng Di (uncooked Radix Rehmanniae Glutinosae), 30 grams, and Shui Niu Jiao (Cornu Bubali), 20 grams, were added. During the chronic stage with dry skin, Gui Wei (Extremitas Radicis Angelicae Sinensis), 20 grams, and Hong Hua (Flos Carthami Tinctori), 10 grams, were added. If there was thick scaling, Wu Shao She (Zaocys Dhumnades) and Qian Cao (Radix Rubiae) were added.

Each day, one packet of these medicinals was decocted with water two times and taken internally in two divided doses. Then the medicinals were decocted a third time and applied externally as a wash. Ten days equaled one course of treatment. During this treatment, patients were also asked to avoid acrid, hot, and rich foods and to avoid using any other external treatment.

Treatment outcomes:

Clinical cure was defined as no scaling or very small, hard to detect scaling, smooth, either still discolored or normally colored skin. Based on these criteria, 30 cases were judged clinicall cured. Obvious improvement was defined as more than 70% resolution of scaling. Thus nine cases were judged to have experienced a marked or obvious improvement. Improvement meant that the scaling was 30-70% resolved. Based on this definition,  11 cases were considered improved. No improvement meant that the scaling was less than 30% resolved, could not be controlled, or became worse. Three cases were determined to have registered no improvement. Therefore, the total amelioration rate was 94%. The length of treatment was as short as three courses and as long as 10 courses.

Discussion:

The Chinese authors explain that this chronic disease is very difficult to treat and is often recalcitrant to therapy. Based on Ye Tian-shi’s famous dictum, "Enduring diseases enter the network vessels," it is the authors’ opinion that quickening of the blood is important both to achieve good initial results and to prevent the disease from recurring even when overt signs and symptoms of blood stasis are not obvious. In this case, it is the enduring and recalcitrant nature of the condition which is itself the sign of blood stasis.

Copyright © Blue Poppy Press, 2004. All rights reserved.

For more information on the Chinese medical treatment of psoriasis, see Liang Jian-hui’s A Hanbook of Traditional Chinese Dermatology available from Blue Poppy Press as well as PsoiaQuell available from Blue Poppy Herbs.


BillyTheKid

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Re: Another look at Chinese medicine
« Reply #3 on: May 19, 2005, 09:40:11 PM »
Psoriasis

"The Treatment of 51 Cases of Psoriasis with Jie Du Huo Xue Tang (Resolve Toxins & Quicken the Blood Decoction)" by Liu Shi-li, Fang Bing, & Zhang Zuo-zhou, Zhong Yi Za Zhi (Journal of Chinese Medicine), #9, 1993, p. 549-550

The authors begin this report by stating that psoriasis is a commonly encountered chronic skin disease making up between 5-10% of the patients in a dermatology out-patient clinic. Based on the Chinese medical principles of clearing heat and resolving toxins, quickening the blood and dispelling wind, the authors composed the formula Jie Du Huo Xue Tang for the treatment of psoriasis which they then used to treat 51 cases of this disease.

Of the 51, 26 were men and 25 were women. They ranged in age from 8.5-66 years of age. Forty-seven had ordinary psoriasis, one had secondary psoriasis, two had psoriasis with erythroderma, and two had articular psoriasis (one of which also had erythroderma). The course of disease had lasted as short as one month and as long as 47 years. Forty-seven cases had been treated previously with various Western and Chinese  medicines, including externally applied plasters.

Jie Du Huo Xue Tang consisted of: Herba Taraxaci Mongolici Cum Radice (Pu Gong Ying), Radix Isatidis Seu Baphicacanthi (Ban Lang Gen), Rhizoma Paridis Polyphyllae (Zao Xiu), Herba Oldenlandiae Diffusae Cum Radice (Bai Hua She She Cao), Rhizoma Sparganii (San Leng), Rhizoma Curcumae Zedoariae (E Zhu), Fructus Tribuli Terrestris (Bai Ji Li), and Herba Solani Nigri (Long Kui).

Based on Chinese medical pattern discrimination, if there was severe blood heat with bright red skin lesions, Rhizoma Imperatae Cylindricae (Mao Gen) and uncooked Radix Rehmanniae (Sheng Di) were added. If wind was flourishing and itching was severe, Zaocys Dhumnades (Wu Xiao She) and Bombyx Batryticatus (Jang Can) were added. If wind and dampness were obstructing the network vessels with joint impediment pain, Herba Gentianae Macrophyllae (Qin Jiao) and Cortex Radicis Dictamni Dasycarpi (Bai Xian Pi) were added. If blood dryness was damaging yin with dry, parched skin lesions and large scales, Radix Angelicae Sinensis (Dang Gui), Radix Salviae Miltiorrhizae (Dan Shen), and Fructus Ligustri Lucidi (Nu Zhen Zi) were added. One ji was used per day, decocted in water and taken in two doses. Four weeks equaled one complete course of treatment. If there was no cure after a single course, from 2-4 courses were given. The patients were examined again once every 1-2 weeks. During the course of treatment, twenty-four patients had blood and urine tests and their liver functions assessed. Also, during the above treatment, patients were not allowed to use any other medications.

Of the 51 patients, 26 or 51% were clinically cured. Twenty-two or 43.1% experienced improvement. And three cases or 5.9% experienced no result. Of the 11 cases with a disease duration of ine year or less, six cases were cured and five were improved. Of the 12 cases with a disease duration of 1-5 years, four were cured and eight were improved. Of the 10 cases with this disease 6-10 years, six were cured and four were improved. Of the 18 cases who had suffered for 11 years or more, nine were cured, six improved, and three got no results. The shortest duration of treatment was two weeks and the longest was six whole courses of treatment, with most cases receiving between 2-3 courses. Among those that were cured, three had relapses which were cured after another course of treatment. No abnormal changes were found in the 24 cases who had had their blood and urine tested and liver functions assessed and there were no obvious side effects to this treatment.


BillyTheKid

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Re: Another look at Chinese medicine
« Reply #4 on: May 19, 2005, 09:42:52 PM »
A Case Study in the Treatment of Psoriasis

by Jane Bean, Lic. Ac

According to Chinese medical theory, most cases of psoriasis involve a vacuity of the constructive and blood which leads to dryness, wind, and loss of nourishment of the skin and flesh. One cause of psoriasis is systemic qi and blood vacuity. Other causes are attack of wind heat or wind cold or pre-existing damp heat, all of which may disrupt the flow of qi and blood in the skin, leading to a local qi and blood vacuity. Once lodged in the skin, these evils may then transform into heat which further damages the constructive and blood. Long-term vacuity of qi and blood in the skin may also lead to blood stasis1. Thus one may see many complicated patterns when treating psoriasis. It is important to look at both the characteristics of the skin lesions and the overall patterns of disharmony when developing a treatment plan. The following case, functionally translated from the Chinese journal literature2, is a good example of this as well as an interesting use of a formula which is usually considered more for the treatment of headache or hypertension than psoriasis.

The patient was a 71 year-old female who had suffered from psoriasis for more than four years. Her skin was scaly and flaked off from time to time. She had unusually severe itching which was difficult to bear, especially at night. Examination showed that her skin had long-standing damage. The lesions were dark and purple around their bases and had mica-like scales on top. In between, there were long, fingernail scratch marks. The patient's body was emaciated and she had dizziness and tinnitus. Her tongue body was dark with dry fur. The left inch and bar pulses were congested and large. The foot pulse was weak. The right inch pulse was fine and weak, while the bar and cubit were deep. Thus her pattern was categorized as liver-kidney yin depletion, wind yang harassing the upper body, fluid damage, and blood stasis with consequent malnourishment of the skin and flesh.

Apppropriate treatment was to subdue the yang and boost the kidneys, calm the liver and extinguish wind. The formula was composed of: Rhizoma Gastrodiae Elatae (Tian Ma), 6g, Ramulus Uncariae Cum Uncis (Gou Teng), 12g, Concha Haliotidis (Shi Jue Ming), 15g, Fructus Gardeniae Jasminoidis (Zhi Zi), 6g, Cortex Eucommiae Ulmoidis (Du Zhong), 9g, Radix Achyranthes Bidentatae (Niu Xi), 15g, Herba Leonuri Heterophylli (Yi Mu Cao), 12g, Radix Salviae Miltiorrhizae (Dan Shen), 15g, Radix Gentianae Macrophyllae (Qin Jiao), 9g, Radix Astragali Membranacei (Huang Qi), 15g, Rhizoma Anemarrhenae Aspheloidis (Zhi Mu), 9g, and Radix Platycodi Grandiflori (Jie Geng), 10g. These were decocted in water and administered internally one ji per day.

Second Examination: After taking six ji of the above medicinals, the dizziness and tinnitus had decreased, while the bases of the skin lesions on the upper limbs had become lighter. The unusually extreme itching had also decreased. After continuing the original formula for 12 more ji, the dizziness and tinnitus were eliminated, scratching was reduced by half, the complexion of the damaged areas of the skin on the whole body became lighter, and the area of damaged skin on the arms was markedly reduced. Because the tendency to hyperactivity of yang was already subdued, the amount of Concha Haliotidis was reduced to 9 grams, and 24 more ji were prescribed. After three months of treatment, there was very little damaged skin on the whole body, and the itching had stopped. The color of the skin and its luster were basically normal. On follow-up after half a year, there was no sign of recurrence. Thus, short-term, the treatment was considered a cure.

Note: The Su Wen (Simple Questions) says: "All counterflow upsurging is ascribed to fire." In this patient's case, the root of the disease pertained to liver-kidney yin depletion resulting in a tendency to hyperactivity of liver yang, blood dryness engendering wind, and improper nourishment of the skin and flesh. Because the right inch pulse was weak, Tian Ma Gou Teng Yin (Gastrodia & Uncaria Drink) plus Astragalus, Anemarrhena, and Platycodon was used in order to boost the qi and engender fluids, moisten the skin and scatter wind. Gentiana Macrophylla and Salvia were added to dispel wind and quicken the blood based on the idea of "To treat wind, first treat the blood; when the blood moves wind, naturally disappears." Leonurus and Uncaria were combined with the previous five ingredients in order to repair the skin damage, improve the microcirculation, and nourish the skin and flesh to promote recovery of the damaged skin.

Endnotes:
1 Manual of Dermatology in Chinese Medicine, Shen De-Hui, Wu Xiu-Fen, & Nissi Wang, Eastland Press, Seattle, WA, 1995, p.216-217

2 From "Effective Treatment with Tian Ma Gou Teng Yin (Gastrodia & Uncaria Drink)" by Mao Shi-you, Hu Nan Zhong Yi Za Zhi (The Hunan Journal of Chinese Medicine), #2, 1991, p. 24 as quoted in Gu Fang Xin Yong Jing Xuan (Carefully Chosen New Uses for Ancient Formulas), Vol. 1, compiled by Guo Tao-mei, Guangdong Science & Technology Press, Guangzhou, 1997, p.277