I hope that my monograph will stimulate joint researches of the dermatologists, rheumatologists, gastroenterologists and microbiologists and approximate complete solution of the riddle of psoriatic disease.
In the future, treatment of psoriatic disease will be directed not to cosmetic and-or anti-inflammatory correction of local manifestations, rather elimination and-or decrease of action of original causes, i.e. in most cases, to the treatment of intestine dysfunctions:
I.e. Hyperpermeability of intestinal walls (subprocess SP1)
and
Growth of populations of Gram+ psoriagenic PsB and Gram(-) TLR4-active bacteria on small intestine mucosa (subprocess SP2).
The efficiency of such treatment will depend on the patient, his/her desire and possibility to control the way of life and diet.
As consequence, remission will be prolonged (or life-long!
), probably supported by regular or periodic intake of medicines (bacteriophages, pre - and probiotics).
Now the further researches of psoriatics are necessary
1) small intestine microflora and ways of its correction
2) small intestine permeability and ways of its correction
3) Definition and studying of:
- Fractionations of blood phagocytes (monocytes Mo and dendritic cells DC).
- Properties of tolerized fractions and both subfractions Mo-R and DC-R.
Let's hope that for this purpose will be available both groups of researchers and financing.
