Author Topic: Clinical study: Probiotics promising as anti-inflammatory agent for psoriasis  (Read 1430 times)

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Offline Grumpy

Hi, thought some of you would be interested in this article, linked from the PHO main website's latest news section. Don't know if anyone else has seen it. I know there's been quite a bit of discussion on this forum about the use of probiotics to help with psoriasis.

This was a study done by researchers at University College Cork, Ireland, at their Alimentary Pharmabiotic Centre. It was presented at the American College of Gastroenterology’s latest Annual Scientific meeting in Washington, DC.

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Extract from article:

Probiotic B. infantis 35624 Promising as Anti-Inflammatory Agent for Patients with Ulcerative Colitis, Psoriasis, Chronic Fatigue Syndrome

Microbial imbalance has been proposed as one possible explanation for the increased incidence of a wide range of inflammatory disorders, including ulcerative colitis, suggesting that altering the balance between good and bad bacteria in the gut may promote an immune regulatory response that could reduce inflammation, according to researchers at the Alimentary Pharmabiotic Centre at University College Cork and Alimentary Health Ltd in Cork, Ireland, who aimed to determine if B. infantis could influence systemic pro-inflammatory biomarkers in patients with inflammatory disease.

The double-blind, placebo controlled study, “Oral Administration of the Probiotic Bifidobacterium Infantis 35624 to Humans Induces Immunoregulatory Responses in Vivo,” included healthy volunteers, and patients with psoriasis, ulcerative colitis and chronic fatigue syndrome. According to the results, plasma levels of the anti-inflammatory cytokine, IL-10, were significantly increased in healthy volunteers and psoriasis patients, but not placebo for eight weeks; while plasma levels of the pro-inflammatory cytokines TNF-alpha and IL-6 were significantly reduced in all patient groups that received B. infantis. In addition, C-reactive protein (CRP) levels were also significantly reduced in psoriasis, ulcerative colitis and chronic fatigue patients at the end of treatment with B. infantis compared to placebo treated patients.

“The human immunological response to B. infantis further supports the hypothesis that manipulation of the microbiota with specific therapeutic microbes can have a significant effect on host inflammatory processes,” said Eamonn M.M. Quigley, MD, FACG, who presented the findings. “This anti-inflammatory effect is not restricted to a specific disease state, suggesting that B. infantis induces a critical cellular response, which may include the induction of regulatory cell subsets.”
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Offline Lazza

Grumpy, thanks so much for the link to the very interesting article!!  Gosh, it seems almost like a tease since it raises so many questions for than it answers.  Well, it actually raises one very critical question: what was the dosage of B. infantis used?  I wouldn't be surprised if they used something fairly hefty, like 20 billion units per dose.  I think only homemade yogurt will get  you anything like that, or else you'd have to spend a lot of money on probiotics.  I also wonder if the precise strain of Bifidobacterium really matters?  There are probably many thousands of known Bidobacterium strains out there.  Upon reading The Probiotics Revolution (Huffnagle) it seems very little clinical testing has been done on any of them, and I get the impression that commercial vendors hype their own special strain when in fact there is relatively little difference (in terms of maintaining good colon flora).

I've been munching on sauerkraut for the past several weeks with very positive results (on my psoriasis, IBS and acid reflux).  However fermented veggies seem to only have Lactobacillus bacteria.  I believe this bacteria works the small intestine whereas Bidobacterium works the colon.  Now the digestive tract is too complex for me to understand but I believe a very green diet, which is chock full of prebiotics, plus Lactobacillus somehow permits the colon flora to sort itself out.

Like I said, many questions.  I certainly would look to making homemade yogurt if I wasn't casein sensitive.  It's not quite as idiot proof to make like sauerkraut but with a yogurt maker, a rather cheap appliance, it becomes rather effortless.


_Lazza

Offline Grumpy

Hi Lazza. Yes, those were also some of the questions that popped into my mind too. Hopefully, the researchers will publish more details about the study and do more research into this.

I just realised that the link I posted doesn't give access to the full article. Hopefully, this one'll work:

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Offline Grumpy

Nope, that didn't work either. Seems you can only access the full version by using the link on the PHO website:

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Offline elgrande

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Found an ebay seller. Quite pricey though if someone with deep pockets fancies giving it a try.

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Only dull people are brilliant at breakfast

Offline elgrande

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N.B the product contains the Bifidobacterium infantis 35624 mentioned.
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Offline Lazza

elgrande, thanks.  Your post jars my memory.  Align brand probiotics contains Bifidobacterium infantis 35624:

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Align was the first brand of probiotics I've ever taken (some 18 months ago) at the suggestion of my GI doctor.  It immediately caused a Herxheimer reaction.  But then it really didn't do anything for my IBS let alone my psoriasis.  However each Align capsule only has perhaps 2 billion units of bacteria, ... perhaps you need much more to really see advantages?

Lastly, Align is a product of Proctor & Gamble.  No doubt P&G has the financial might to do studies and exhaustively market them in a positive light.  Again I have my doubts as to whether B. infantis 35624 is superior to any other B. infantis or any Bifobacterium strain for that matter.


_Lazza

Offline Eveloftus

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As Lazza said, home made yoghurt left to "ferment"for 24 hours as bj does, is a good option, it will contain many more bacteria than the probiotic supplements, in the trillions (per serving) as opposed to billions. I looked at the starter I use, it contains B. infantis (plus various strains of lactobacilli). It is probable like Lazza said that B.infantis is not the only effective strain.

Would it be possible Lazza, to use a different term than "Herxheimer reaction" for the reaction you got with Align? Herxheimer is a very specific medical term used for the body's reaction to treating gram negative bacterial infections (such as syphilis) with antibiotics. Perhaps you could say "a healing reaction"?

Offline Lazza

Eve, here is the definition of Herxheimer's reaction:

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As you can see, Herxheimer reaction also applies to Candida die-off, which is what I experienced.  And so Herxheimer reaction doesn't only apply to the effects of treating bacterial infections.


_Lazza

Offline Eveloftus

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Wikipedia is not a medical dictionary, so I wouldn't trust their definitions. Also, "Candida die-off" is simply not a medically recognized condition.

Look in any medical dictionary and you will see that Herxheimer reaction refers only to the reaction occurring when gram negative bacterial infections such as syphilis, Borreliosis, Lyme disease etc. are treated.