digestive enzymes / deficiencies

[igH]

Computational Approach to Identify Enzymes That Are Potential Therapeutic Candidates for Psoriasis

In this study, we attempted to explore potential therapeutic candidates for psoriasis by utilizing bioinformatic methods. We have presented essential proteins from upregulated and downregulated genes in psoriasis; some of these findings have been supported by experimental evidence reported in the literature. Of particular interest are the predicted essential enzymes that are important proteins related to the pathogenesis of psoriasis; these enzymes can be explored as therapeutic or drug target candidates. Further studies should be conducted to determine the role of these candidate enzymes in psoriasis and to explore agonists of the upregulated candidates or antagonists of downregulated candidates as drug targets by exploiting the property of multiple targeting. These results will aid future drug discovery efforts, enabling drug development in a more timely and cost effective manner.

downloads.hindawi.com/journals/er/2011/826784.pdf

[igH]

i'm still looking into the possibilities of the role of the pancreas in p; here are a few more papers in that regard....

The Exocrine Function of the Pancreas in Psoriasis

During the past quarter century, a number of reports have suggested that psoriasis is induced or aggravated by altered exocrine pancreatic function. The present study is intended to clarify the exocrine role of the pancreas in psoriasis.

Ingels1 in 1953 claimed good clinical results in the majority of 36 psoriasis patients who received pancreatic enzyme replacement therapy. Earlier favorable clinical reports of Dragstedt, Becker, Stewart, Clark, and Walsh2-4 using alcoholic pancreatic extract, "lipocaic," are well known. Clinical improvement with a variety of pancreatic preparations has been reported by other investigators.5-7 At present, there are a number of commercial preparations available whose primary constituents are pancreatic enzymes, which have been said to be of value in psoriasis.

Madden and Karon8 found no significant variation in pancreatic exocrine function in psoriasis. They employed only indirect measurement through study of fecal nitrogen, fecal fat, . . .

unfortunately the article doesn't have an abstract... You are not allowed to view links. Register or Login

[igH]

Disturbances of the incretory and excretory pancreatic functions in patients suffering from psoriasis in combination with chronic opisthorchosis

The aim of the study was to evaluate the incretory and excretory functions of the pancreas in patients suffering from psoriasis in combination with chronic opisthorchosis (CO). The subjects were 30 patients with psoriasis and CO, 20 patients with psoriasis without helminthiasis, 20 patients with CO, and 12 healthy individuals. The incretory pancreatic function was studied by measuring serum levels of pancreatic hormones (insulin, glucagon, and C-peptide) using radioimmunoassay with standard sets; the excretory function was studied by means of measuring serum levels of pancreatic enzymes (amylase and lipase) using a biochemical technique. Proteolytic capacity was evaluated using PABA test (per cent of the renal excretion of paraminobenzoic acid); amylolytic capacity was evaluated using coprogram results. The study revealed disturbances in the incretory and excretory functions of the pancreas in patients suffering from psoriasis or psoriasis with CO. The latter subgroup had more prominent disturbances.

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The clinical and functional status of the pancreas in patients with psoriasis concurrent with chronic opisthorchiasis

Seventy patents including 30 with psoriasis concurrent with chronic opisthorchiasis, 20 with psoriasis without opisthorchiasis, and 20 with chronic opisthorchiasis, were examined. Structural changes in the pancreas and its endocrine and exocrine functions were evaluated. Patients with psoriasis alone or in combination with chronic opisthorchiasis were found to have signs of pancreatic lesion with its impaired endocrine and exocrine functions. These impairments are more pronounced in the group of patients with mixed pathology.

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[igH]

Pancreatic Extracts in the Treatment of Psoriasis

An Evaluation of Entozyme and Lipan

Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In the past five years, there has been an increased interest in the use of pancreatic extracts in the treatment of patients with psoriasis. The advocates of pancreatic therapy have claimed improvement and remissions in as high as 77% of the patients treated.1-3

Pancreatin N. F. is a pancreatic extract containing three enzymes—amylase, lipase and trypsin— which act in the intestinal tract on carbohydrates, fats, and proteins respectively. The two products containing pancreatin which were commercially available at the beginning of this investigation were Entozyme and Lipan. In addition to containing pancreatin, Entozyme contains pepsin and bile salts, while Lipan contains vitamin Bi and vitamin D. Since the effectiveness of both Entozyme and Lipan was attributed to the action of pancreatin, these drugs were considered to be essentially the same.

The rationale for the use of pancreatin has rested on the premise . . .

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[igH]

Serum pancreatic lipase [EC 3.1.1.3] activity, serum lipid profile and peripheral blood dendritic cell populations in normolipidemic males with psoriasis

Abstract

The purpose of the study was to explore serum pancreatic lipase activity and the serum lipid profile in relation to peripheral blood dendritic cell subsets and disease severity in males with psoriasis.

Material and methods

The study population consisted of 22 normolipidemic males with psoriasis and 12 aged-matched and body mass index (BMI)-matched healthy males. The percentages of peripheral blood dendritic cell (DC) subsets were evaluated using appropriate monoclonal antibodies and flow cytometry. The serum pancreatic lipase activity and the lipid profile were determined using standard enzymatic and colorimetric techniques.

Results

Pancreatic lipase activity was increased (p = 0.56421), high-density lipoprotein (HDL)-cholesterol concentration (p = 0.00584) was significantly decreased, triglyceride (p = 0.00766) and VLDL-cholesterol (p = 0.00765) levels were significantly increased in serum of psoriatic patients compared to controls. The serum pancreatic lipase activity showed significant correlation with serum triglyceride (r = 0.42; p = 0.04721) and serum VLDL-cholesterol levels (r = 0.42; p = 0.04721) in psoriatic individuals. In psoriatic patients the percentage of myeloid DCs was increased (p = 0.54932), the percentage of lymphoid DCs was decreased (p = 0.14210) and myeloid DC/lymphoid DC ratio was significantly increased (p = 0.03569) compared to healthy individuals.

Conclusion

The direct cause of the abnormal lipid profile in psoriasis and its relationship with the immune system disturbances remains unclear. The reciprocal relationship between serum pancreatic activity and serum triglyceride level appears to confirm the hypothesis about abnormal lipid metabolism in psoriasis.

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Psoriasis and serum lipid abnormalities
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Accumulation of Oxidized Low-Density Lipoprotein in Psoriatic Skin and Changes of Plasma Lipid Levels in Psoriatic Patients

Background. Psoriasis is a chronic inflammatory skin disease characterized by an accelerated turnover of epidermal cells and an incomplete differentiation in epidermis with lesion. However, the exact etiology of psoriasis is unknown. Abnormalities in essential fatty acid metabolism, free radical generation, lipid peroxidation, and release of lymphokines have been proposed. Objective. Our purpose was to evaluate the plasma lipids and oxidized low-density lipoprotein accumulation in psoriatic skin lesion in order to ascertain the possible participation of oxidative stress and oxidative modification of lipids in pathogenesis of psoriasis. Methods. The study group included 84 patients with psoriasis, and 40 sex- and age-matched healthy volunteers. Blood lipid profile was determined. Psoriatic and nonlesional skin samples of psoriatic patients were evaluated for the presence of oxidized low-density lipoprotein by using an immune-fluorescent staining method. Results. The mean levels of lipids (total cholesterol, triglyceride, and LDL cholesterol) in patients with psoriasis were found to be significantly higher than those of healthy subjects. Psoriatic skins were shown positive oxidized low-density lipoprotein staining. There was no staining in nonlesional skin samples of the same individuals. Conclusion. Lipid peroxidation mediated by free radicals is believed to be one of the important causes of cell membrane destruction and cell damage. This study shows for the first time the accumulation of oxidized low-density lipoprotein in psoriatic skin lesion. We believe that accumulation of ox-LDL in psoriatic skin may have an important role in the immune-inflammatory events that result in progressive skin damage.

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Serum lipids abnormalities and psoriasis
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Lipid disturbances in psoriasis: an update
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Lipid Disturbances in Psoriasis: An Update
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