Lack of bile salt possible cause?

[Ayub]

Hi everyone

Not sure if this has been mentioned before but I was wondering whether the theory of lack of bile salt be possibly be an explanation on why a number of people succeed through diet and Vitamin D etc

Bile salt is a chemical produced in the liver and stored in the gallbladder. It aids in the digestion of fats and helps in the elimination of toxins from the body. Incomplete digestion increases levels of undigested protein in the bowel and creates compounds called polyamines. These contribute to the excessive formation of skin cells. Polyamines have been found to be increased in individuals with psoriasis. Toxins from bacteria in the gut have been found to be higher than normal in individuals with psoriasis. These toxins increase skin cell proliferation.

It is possible that maybe certain proteins such as gluten or other proteins found in other suspect food such as dairy nightshade etc cannot be broken down properly because of the lack of bile salt. Bile salt comes from the gall bladder which has the ability to stock up on fat that can be used as a source of calories in illness and famine, essential fatty acids and fat soluble vitamins(A, D, E, K). This again may explain why in many people Vitamin D and essential oil have to be replenished and taken on a regularly basis.


"Psoriasis is a chronic skin condition in which skin cells are produced too quickly for the body to shed, thus causing lesions. Some scientists believe psoriasis is related to insufficient toxin elimination in the body. Researchers in Hungary tested their hypothesis that psoriasis is caused in people who do not produce enough bile. K. Gyurcsovics and L. Bertók of Petz Aladár County Educational Hospital in Gyor, Hungary, treated one group of psoriasis sufferers with conventional medication and another group with bile salts taken orally over a period of two years. Of the group on conventional medication, 24.9 percent became asymptomatic, while 78.8 percent of those on bile salts became asymptomatic. This indicates a more effective treatment for psoriasis is bile salts."


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[riaY]

Hmmm this is going to take a lot of consideration from me. I have a condition called bile acid malabsoption. This appeared/started after treatment for Legionnaires disease 20 odd years ago. Interestingly my p started shortly after  I'll have to do a bit of research and speak to my consultant to see what he thinks about a connection.

[mitzi]

very interesting. Any suggestion on which product to take for starters.

[Lazza]

vorden, hi.  I am not sure why dairy causes my immune system such distress.  I always consumed dairy, often in great quantity, with the only issue being some intestinal gas depending on the type of dairy involved.  But then when I reached past 50 something changed.  I developed irritable bowel syndrome.  Without getting graphic, my colon was obviously messed up.  Then at 52 I developed severe psoriasis.  How might dairy be involved in all this?

Although I have some doubt, I believe that perhaps I was the victim of colon damage due to colon infestation by bacteria/fungus.  This damage causes increased colon lining permeability, aka Leaky Gut Syndrome.  As mentioned briefly in The China Study [Campbell], a good book by the way, pieces of protein can slip through the colon lining.  This causes an autoimmune response in some people.  Casein apparently mimics human protein, thus confusing the immune system.  And so dairy sensitivity is caused by casein.  Dairy intolerance is caused by the inability to digest lactose.  I probably suffer from both.

The casein sensitivity is addressed by clearing out the colon of bad bacteria/fungus so that the colon lining can heal.  During this time one must carry on with a 100% dairy free diet.

I have not thought too much about digestive enzymes, although there are indeed articles and testimonials on the web that make me tempted to try them out.  But it is a bit complex.  For example, I see that there were studies that say taurine makes psoriasis worse.  Yet other articles say it can be helpful in treating psoriasis.  At any rate, I do suspect I am deficient in certain digestive enzymes.  Although my irritable bowel syndrome situation is largely resolved I can see where supplementation of certain enzymes might be of help.  But the topic is complex, and I am reluctant to use my body as a guinea pig!


_Lazza


PS - btw, I happen to be taking choline (lecithin) and B complex vitamins.

[Ayub]

I have used marine lecithin which has helped me in the past. Interestingly marine lecithin has a substantial amount of choline in it.

Am glad to hear that the bile salt was the missing jigsaw to your theory. I believe more studies should be directed to this area as I feel it may explain someway towards the inability of digesting certain protein and the leaky gut syndrome.

In particular I would be interested to know more about bile salt supplements how it works if there are any compilcations that may arise from it. In the study below they used oral bile acid (dehydrocholic acid) supplementation, am pretty sure I wont find that over the counter  .



Abstract
The authors demonstrated significant curative effect of bile acids (Suprachol; Acidum dehydrocholicum) in 551 psoriatic patients. The clinical efficiancy was evaluated by means of PASI-score (Psoriasis Area Severity Index). During this treatment (1-8 weeks) 434 patients (78.8 per cent) became asymptomatic. However, the traditional therapy resulted in 62 patients (24.9 per cent) of 249 sick persons a recovery (p < 0.05). In acute form of psoriasis (184 patients) this curative effect of bile acids was elevated (95.1 per cent). Two years later 319 patients (57.9 per cent) of bile treated 551 people were asymptomatic in contrast with 15 people (6.0 per cent) of 249 traditional treated patients (p < 0.05). In same time among the patients which were treated in acute form of psoriasis 10 (7.2 per cent) of 139 controls and 147 (79.9 per cent) of 184 bile-treated individuals were asymptomatic (p < 0.01). On the basis of their clinical observations (digestive disorders, ultrasonical confirmed gallbladder complaints, etc.) authors supposed that the deficiency of bile acids and the consecutive endotoxin translocation might play a role in the pathogenesis of psoriasis. In normal conditions the bile acids as detergent (physico-chemical defense) can protect the body against enteral endotoxins while split them to atoxic fragments and so preventing consecutive cytokin liberation.

PMID: 10827473 [PubMed - indexed for MEDLINE]

[scratchydude]

Calm down vorden 

There's too much to read, could you resume in a few words what you have been so excited about ?

[Ayub]

Hi Vorden

Can you please summarise your regime including all the supplements your using?

[Eveloftus]

So then Vorden, according to your theory, would taking anti-depressants like SSRIs which inhibit reuptake of serotonin, thus increasing its levels, make psoriasis worse?

[Lazza]

Hi Vorden

Can you please summarise your regime including all the supplements your using?

But in short :

i excluded all oils from my diet except flaxseed oil blended with cottage cheese. Also used DHA and EPA - fish oils.
Used probiotics - 10 species
Constant detoxification
Supplements:
vit. B complex
Vit E
No vit C and A at all
Taurine
Magnessium, potassium, copper, selenium, zinc,, dhea, milk thistle, lecithin, chela-min sport formula ( this is Polish product contains minerals check in the internet as I don't remember all ingredients ), l-lysine , L-l-metionine , sometimes L-arginine ...
 
What else
eat steamed chicken or fish, no white bread , no sugar, no salt, checked glikemic index of food and prefer low GI, beetroot salads or juice , VASA dietetic bread, soy spread and milk, reduced proteins to 90 grams a day, no sodas, no milk .
Garlic, onions , curcumin, cayenne pepper ... 
Eat 4 times a day, a lot of water

Herbs

Etc ...

Hi.  You mention "constant detoxification".  What specifically are you taking to achieve this?

Thanks.


_Lazza


PS - based on what you wrote, I cannot see how you are eating anything close to 90 grams of protein each day.  I am on a generally similar diet and I don't think I eat more than 50-60 grams/day, which is still fine.  BTW, I lost almost 10 kilos in my diet during the first four months.  My weight is now perfect (BMI = 23-24).

[colsta]

Not sure if this is related

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The authors have tested the hypothesis that the deficiency of bile acids and the consequent endotoxin translocation might play a role in the pathogenesis of psoriasis. Under normal conditions the bile acids act as detergents (physico-chemical defense) and can protect the body against enteric endotoxins by splitting them into nontoxic fragments and thus preventing the consequent release of cytokines [Persp. Biol. Med. 21 (1977) 70]. A total of 800 psoriasis patients participated in the study and 551 were treated with oral bile acid (dehydrocholic acid) supplementation for 1-8 weeks. The efficacy of the treatment was evaluated clinically and also by means of the Psoriasis Area Severity Index (PASI score). During this treatment, 434 patients (78.8%) became asymptomatic. Of 249 psoriatics receiving the conventional therapy, only 62 (24.9%) showed clinical recovery during the same period of time (P<0.05). The curative effect of bile acid supplementation was more pronounced in the acute form of psoriasis (95.1% of the patients became asymptomatic). Two years later, 319 out of the 551 acute and chronic psoriasis patients treated with bile acid (57.9%) were asymptomatic, compared to only 15 out of the 249 patients (6.0%) receiving the conventional treatment (P<0.05). At the end of the 2-year follow-up, only 10 out of 139 acute psoriasis patients (7.2%) receiving the conventional therapy and 147 out of 184 bile acid treated patients (79.9%) were asymptomatic (P<0.01).To conclude, the results obtained suggest that psoriasis can be treated with success by oral bile acid supplementation presumably affecting the microflora and endotoxins released and their uptake in the gut.

PMID: 14643904 [PubMed - as supplied by publisher]