Author Topic: Lack of bile salt possible cause?  (Read 10624 times)

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Offline igH

Re: Lack of bile salt possible cause?
« Reply #50 on: November 02, 2011, 02:31:13 PM »
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Hi Vorden

Hows your programme going at the moment still clear??

hi,
I was banned as Vorden

Yes , still clear , sometimes small dot will apear but after a coulple of days it vanishes.

this started happening to me after i had cleared, they appear in the inside of my elbows...  ::)

but on a serious note, if a member is banned, then all their postings gets deleted? :o  sorry for necroposting, but it seemed kinda odd & i was really interested & it seemed weird if i would have missed out on any valuable info which might have been posted...
« Last Edit: November 02, 2011, 02:43:22 PM by igH »

Offline igH

Re: Lack of bile salt possible cause?
« Reply #51 on: January 10, 2012, 03:49:54 PM »
it always strikes me as odd as to why successful studies aren't being followed up!!! anywho, here's something interesting...

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We report three Japanese patients with psoriasis vulgaris associated with nonalcoholic fatty liver disease in which the skin lesions dramatically resolved after treatment of the fatty liver disease with ursodeoxycholic acid (UDCA). According to the literature, arachidonic acid is released from phospholipid by phospholipase A2 (PLA2) and is a precursor of eicosanoids, including prostaglandins, leucotrienes, and thromboxanes, which are potent inflammatory mediators. PLA2 activity has been reported to be significantly raised in the serum and skin tissue of patients with psoriasis. UDCA has been reported to suppress the increased activity of group IIA PLA2, a secretory low-molecular-weight PLA2 (PLA2IIA), in HepG2 cells (a human hepatoblastoma-derived cell line) and in gallbladder and gallbladder bile samples from patients with cholesterol stones. Thus, UCDA may improve the skin lesions of patients with psoriasis by suppressing PLA2IIA activity.

Psoriasis treated with ursodeoxycholic acid: three case reports
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Ursodiol, also known as ursodeoxycholic acid and the abbreviation UDCA, is one of the secondary bile acids, which are metabolic byproducts of intestinal bacteria.

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Offline igH

Re: Lack of bile salt possible cause?
« Reply #52 on: January 14, 2012, 11:05:30 AM »
there are also correlations in regards to hypochlorhydria/achlorhydria... You are not allowed to view links. Register or Login

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gastric secretory function in psoriatic patients is characterized by reduced hydrochloric acid and pepsin outputs

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In a series of 400 patients with skin disorders and suspected B vitamin deficiency resistant to local treatment, he investigated stomach acidity. Table 4 summarizes his findings.

He also observed the severity of acid deficiency was in direct proportion to both the duration and severity of the skin disease and digestive symptoms. Improvement in general health and skin condition was observed following treatment with HCl and B-complex (as brewer's yeast) in virtually all patients with impaired HCl production. Cases with very moderate HCl deficiency showed rapid improvement and early signs of intolerance to the acid, which he believed indicated a return to normal secretion.17 While Allison did not claim the ten dermatology conditions were always due to B vitamin and HCl deficiency, his observations and therapeutic results suggest gastric acidity should be investigated in individuals presenting with these conditions.

Ayers also commented on a correlation between eczema and psoriasis and reduced gastric secretions. He found 8 of 11 patients with eczema and 10 of 19 patients with psoriasis had functional hypoacidity.

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The Relation of Hydrochloric Acid and Vitamin B Complex Deficiency in Certain Skin Diseases*
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Fumaric acid may not be regarded as an antipsoriatic drug. Beneficial effects on psoriatic lesions may be explained by secondary changes such as the acidification of gastric juice in cases of anacidity or hypacidity

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Fumaric acids have been proven to be an effective therapy in patients with psoriasis even though the mechanisms of action are not completely understood.

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Offline igH

Re: Lack of bile salt possible cause?
« Reply #53 on: January 14, 2012, 11:12:37 AM »
might as well also add the data re pancreatic/digestive enzymes here...

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Entozyme,® a pancreatic extract taken orally, was used in 36 cases of psoriasis previously recalcitrant to other treatment. In 24 cases this extract was the only treatment given, and good response occurred in 19 cases within 4 weeks to 3 months, with complete clearing in four cases. In 11 of 12 cases in which local treatment was supplemented by Entozyme, lesions cleared in 2 weeks to 3 months or longer.

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The Exocrine Function of the Pancreas in Psoriasis
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In the past five years, there has been an increased interest in the use of pancreatic extracts in the treatment of patients with psoriasis. The advocates of pancreatic therapy have claimed improvement and remissions in as high as 77% of the patients treated.1-3

Pancreatin N. F. is a pancreatic extract containing three enzymes—amylase, lipase and trypsin— which act in the intestinal tract on carbohydrates, fats, and proteins respectively. The two products containing pancreatin which were commercially available at the beginning of this investigation were Entozyme and Lipan. In addition to containing pancreatin, Entozyme contains pepsin and bile salts, while Lipan contains vitamin Bi and vitamin D. Since the effectiveness of both Entozyme and Lipan was attributed to the action of pancreatin, these drugs were considered to be essentially the same.

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Offline igH

Re: Lack of bile salt possible cause?
« Reply #54 on: January 14, 2012, 11:16:19 AM »
diamine oxidase deficiency...

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Offline scratchydude

Re: Lack of bile salt possible cause?
« Reply #55 on: March 08, 2012, 10:22:21 PM »
I read the whole topic but I still do not understand how enzymes are related to increased bile acid in the body ? if they are of course..Do they increase bile acid production in somekind of way?

Can we have a follow up from the people having tried oral bile acid supplementation, dehydrocholic acid ?

UPDATE: I think I might stop putting olive oil on my food for a while as it seems to decrease bile acid release.

A pleasant thing I notice is whenever I put water on parts of my skin with P, let's say my hand, nothing happens and P remains. BUT, when I put some saliva on the same lesion then the redness turns to pink and the skin looks really less inflammaed.
I know some of you won't believe me, but I managed to clear completely a small spot of P on the upper part of my thumb ONLY by puting some salvia on it for several days (one time in the morning and one time in the evening during a week). While this can't be seen as a solution (even though the P didn't came back on that spot) it conforts me with this interesting idea that deficient bile production may well be part of the problem.

But isn't high bile acid associated to higher risk of cancer?
« Last Edit: March 10, 2012, 03:12:24 PM by scratchydude »

Offline igH

Re: Lack of bile salt possible cause?
« Reply #56 on: March 12, 2012, 01:39:00 PM »
When food is emptied from the stomach into the small intestines, it is mixed with bile salts that are produced in the liver and stored in the gall bladder. Remember, bile salts are much like soap and are critical for our digestion and absorption of fats. In addition to bile from the gall bladder, the pancreas releases digestive enzymes that are critical to digestion. And lest you forget, much of the digestive process happens at the tiny structures in our intestines—the villi and microvilli. Now let’s see how lectins interact with the intestinal lining to produce autoimmunity.

Lectins such as WGA bind to a receptor in the microvilli, allowing WGA to be transported into the body. This is the mechanism of the autoimmune cascade I described above. If the gut wall (microvilli) becomes damaged, the entire contents of the intestines can now make its way into your system. Yes, that’s as bad as it sounds. You are not only in a position to create antibodies against WGA, which leads to autoimmunity, but you now have the potential to develop multiple allergies due to a permeable gut lining and inadequately digested food. This is how you can develop allergies to chicken, beef, apples, or other normally benign foods.

Additionally, if your gut is damaged, you expose yourself to a host of chemicals that would normally remain in the intestines. This can lead to conditions such as multiple chemical sensitivity syndrome, which is regarded more as a psychiatric problem than legitimate medical condition.

Let me be crystal clear about this: Anything that damages the gut lining (including bacterial, viral, and parasitic infections, as well as alcohol, grains, legumes, and dairy) can predispose one to autoimmunity, multiple chemical sensitivities, and allergies to otherwise benign foods.

As my Brazilian Jiu-Jitsu coach says, “This no opinion is, this fact is.”

“If the gut wall (microvilli) becomes damaged, the entire contents of the intestines can now make its way into your system.” [Note from Tim: this is where the "feces in the bloodstream" post title comes from]

cntd...

Offline igH

Re: Lack of bile salt possible cause?
« Reply #57 on: March 12, 2012, 01:39:22 PM »
Full of Bile

While this digestive disaster is taking place, there are several other problems brewing. As you recall, the function of the gall bladder is to release bile salts into a meal as it is emptied into the duodenum from the stomach. When the intestinal wall is damaged, the chemical messenger, cholecystokinin (CCK), is not released. CCK usually sends the “on” switch to the gall bladder and the secretion of pancreatic digestive enzymes. When this signal is blocked, we do not properly digest our foods, particularly fat and protein. The lack of bile release allows cholesterol crystals to form in the gall bladder, which leads to gall stones. The standard medical practice of removing the gall bladder is effectively killing the “canary in the coal mine.” Gall stones are a symptom of a problem, an alarm. Instead of treating the cause (remove grains) we cut out the gall bladder. People who have had gall bladder removal are almost certainly undiagnosed celiacs and likely have a number of other progressive diseases. In my experience, these individuals are plagued with digestive problems, culminating in dysphagia, or difficulty swallowing.

Achtung!
The disruption of CCK and related hormones (PYY, adiponectin) in the signaling cascade of digestion is a really big deal. Not only is the digestive process severely damaged, much of our satiety signaling is taken offline as well. We cannot properly digest our food, we are always “hungry,” and the very food we crave, refined grains and sugary junk, happens to be the cause of the problem.

It Gets Better
Another piece of the chemical defense system used against us by grains is a group of enzymes called protease inhibitors. Protease inhibitors prevent the breakdown of proteins. This means that when you consume grains you do not effectively digest the protein in your meal. Protease inhibitors also stymie the digestion of lectins such as WGA, making these already difficult-to-digest items virtually indestructible. This leaves more large proteins in the intestinal contents, which increases our likelihood of developing autoimmunity, allergies, or chemical sensitivities.

Osteoporotic Much?
If you do not have a bellyache thinking about grains by now, let’s look at one more player: antinutrients such as phytates. Phytates are important for seeds and grains because they tightly bind to metal ions (like magnesium, zinc, iron, calcium, and copper), which are crucial for the growth and development of the grain. If the metal ions are not tightly bound by the phytates, the process of germination can happen prematurely and this can spell disaster for the grain.

When we consume grains, the phytates are still active and powerfully bind to calcium, magnesium, zinc, and iron. This means the calcium, magnesium, zinc, and iron are unavailable for absorption. Because of the action of antinutrients such as phytates combined with the gut damaging characteristics of lectins and protease inhibitors, our Neolithic ancestors lost an average of six inches in height vs. our Paleolithic ancestors due to the Neolithic diet of grains and legumes. Are you concerned about osteoporosis or iron deficiency anemia? Do you suffer from fatigue or heart problems that might be caused by magnesium deficiency? Have you diligently consumed a “smart” diet of whole grains, legumes, and low-fat dairy as per the recommendations of your dietician and doctor? Do you see how ridiculous that suggestion is in light of what you now know about grains, legumes, and dairy?

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Offline igH

Re: Lack of bile salt possible cause?
« Reply #58 on: March 26, 2012, 10:47:14 AM »
"The discovery of the physico-chemical host defence is closely connected with the endotoxin research. It is well known that the toxic effects of endotoxins under experimental conditions can be induced only when they are administered parenterally. However, in naturally occurring entero-endotoxemic diseases (e.g. septic and various shocks, etc.), the endotoxin is absorbed from the intestinal tract. The cause and mode of translocation have been unknown. The generally used experimental shock models differ from natural diseases only in the mode by which endotoxin enters the blood circulation. If the common bile duct of rats was chronically canulated (bile-deprived animals) orally administered endotoxin was absorbed from the intestinal tract into blood circulation and provoked endotoxin shock. This translocation of endotoxins and the consequent shock can be prevented by sodium deoxycholate or natural biles. The bile acids split the endotoxin macromolecule into atoxic fragments. A similar detoxifying detergent action plays a significant role in host defence against infectious agents with outer lipoprotein structure (e.g. so-called ‘big’ viruses). This defence mechanism of macroorganisms based on the detergent activity of bile acids (end-products of the cholesterol metabolism) is called as physico-chemical defence system. Therefore, bile deficiency and the consequent endotoxemia are important components in the pathogenesis of certain diseases (e.g. sepsis, intestinal syndrome of radiation disease, hepato-renal syndrome, parvovirus infection, herpes, psoriasis, atherosclerosis, etc.). Bile acids may be used for the prevention and/or therapy of the above mentioned clinical conditions." - You are not allowed to view links. Register or Login

"In patients at diagnosis, elevated somatostatin levels were associated with increased gallbladder fasting volume, whereas decreased cholecystokinin secretion was responsible for the reduced gallbladder emptying. Gluten-free diet reversed these abnormalities." -  You are not allowed to view links. Register or Login