PubMed NIH study - curcumin (turmeric extract) ameliorates psoriasis

[missminni]

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Neuroscience Research Laboratory, Methodist Research Institute, Clarian Health, Indianapolis, IN 46202, USA. You are not allowed to view links. Register or Login
Abstract

The immune system has evolved to protect the host from microbial infection; nevertheless, a breakdown in the immune system often results in infection, cancer, and autoimmune diseases. Multiple sclerosis, rheumatoid arthritis, type 1 diabetes, inflammatory bowel disease, myocarditis, thyroiditis, uveitis, systemic lupus erythromatosis, and myasthenia gravis are organ-specific autoimmune diseases that afflict more than 5% of the population worldwide. Although the etiology is not known and a cure is still wanting, the use of herbal and dietary supplements is on the rise in patients with autoimmune diseases, mainly because they are effective, inexpensive, and relatively safe. Curcumin is a polyphenolic compound isolated from the rhizome of the plant Curcuma longa that has traditionally been used for pain and wound-healing. Recent studies have shown that curcumin ameliorates multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease in human or animal models. Curcumin inhibits these autoimmune diseases by regulating inflammatory cytokines such as IL-1beta, IL-6, IL-12, TNF-alpha and IFN-gamma and associated JAK-STAT, AP-1, and NF-kappaB signaling pathways in immune cells. Although the beneficial effects of nutraceuticals are traditionally achieved through dietary consumption at low levels for long periods of time, the use of purified active compounds such as curcumin at higher doses for therapeutic purposes needs extreme caution. A precise understanding of effective dose, safe regiment, and mechanism of action is required for the use of curcumin in the treatment of human autoimmune diseases.

PMID: 17569223 [PubMed - indexed for MEDLINE]


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Adv Exp Med Biol. 2007;595:343-57.
Beneficial role of curcumin in skin diseases.

Thangapazham RL, Sharma A, Maheshwari RK.

Uniformed Services University of Health Sciences, Bethesda, MD, USA. You are not allowed to view links. Register or Login
Abstract

In recent years, considerable interest has been focused on curcumin a compound, isolated from turmeric. Curcumin is used as a coloring, flavoring agent and has been traditionally used in medicine and cuisine in India. The varied biological properties of curcumin and lack of toxicity even when administered at higher doses makes it attractive to explore its use in various disorders like tumors of skin, colon, duodenum, pancreas, breast and other skin diseases. This chapter reviews the data on the use of curcumin for the chemoprevention and treatment of various skin diseases like scleroderma, psoriasis and skin cancer. Curcumin protects skin by quenching free radicals and reducing inflammation through nuclear factor-KB inhibition. Curcumin treatment also reduced wound-healing time, improved collagen deposition and increased fibroblast and vascular density in wounds thereby enhancing both normal and impaired wound-healing. Curcumin has also been shown to have beneficial effect as a proangiogenic agent in wound-healing by inducing transforming growth factor-beta, which induces both angiogenesis and accumulation of extracellular matrix, which continues through the remodeling phase of wound repair. These studies suggest the beneficial effects of curcumin and the potential of this compound to be developed as a potent nontoxic agent for treating skin diseases.

PMID: 17569219 [PubMed - indexed for MEDLINE]

[LittlePinkPuss]

I am taking curcumin for inflammatory bowel disease - really helping.

So it can only be good for my psoriasis as well, since they are both autoimmune diseases

Had a small P flare at Xmas due to stress and stuffing myself with inflammatory foods. But I have since cleared that up by being very strict with my diet, so skin looks perfect again.   

Thank you for posting. I am sure the details will be helpful to others.

[Vladex]

just ordered 100 grams , will report when it comes

[scratchydude]

I am sticking to a diet right now but I plan to take some curcumin supplements in the future.

Meanwhile, I though I would do some research about the supplements and found this report from consumerlab to be pretty worrying..

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Anyone has some kind of access to the product reviews of consumerlabs ? because I'm interested in a brand "NSI" You are not allowed to view links. Register or Login and I'm concerned about the presence/absence of toxic stuff in it (the brand was found to contain lead back in 2008)

[Vladex]

I have ordered a bulk powder form, should come in any day now.

[jjoblogs1]

 

[Vladex]

I have ordered a bulk powder form, should come in any day now.

ok , I received a package about 30 minutes after I wrote this and now I have it. It is as expected an exotic orange powder with a slight aggreable smell . I am not sure how to use it yet, supposedly it's fat soluble so I'll just sprinkle it on an oily food . What do you think about topical use? It's very expensive though , 100 grams for 52$

[Vladex]

I just applied  curcumin on my forehead to see how it's going and it's really really orange. I put it like pretty much everything else with coconut oil so it kind of sticks but it's hard to put and when it gets on clothing it does put a good stain on it. I really try to be careful with it considering now it's 2grams/1$

[Vladex]

ok anybody with me trying to use curcumin ?
I applied it yesterday topically and it didn't go well I am afraid. It is really exotic orange color and made me look funny but once I tried to remove it , it was the hardest thing and I left all yellow stains all over my house and even the pillows . It's really strong stuff for a little bit so I don't see how I can apply it anymore . I don't think it absorbed that well although I only had it for 5 hours or so . The taste is also not that palatable so to speak . I mean I just started so maybe I'll get used to it but it has a sort of an unappetizing smell. All of this could be good of course and it could mean it really works, it's just that I don't know how at this point. Maybe I'll just put it in capsules and take it with fatty food or simply with coconut oil.

[scratchydude]

"I left all yellow stains all over my house and even the pillows . "

Lol. Just try to take a supplement like this one:
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I'll be taking it once I see I can't clear on diet & shakes alone. It is said that bioperine helps absorbing the curcumin, I wonder if it also helps to absorb the vitamin D..