All I was told that with [glb]mtx[/glb], which I have been taking for the past year and a half - with only mixed success (initially it worked well, but now has plateau'ed out) - all you havge to avoid is alcohol. However, I was also told, by a different dermatologist, that it's OK to have the odd drinkie.
The top dermatologist also said that I had to lose the blubber, because the fat was having a detrimental effect on the workings of [glb]mtx[/glb].
Joe M