Thanks Spotted owl! The only ingredient I see that could be helpful is glucosamine. Any other one?
Actually there are a couple of more. EGCG and the theaflavin and resveratrol from the green tea does have some background in fighting inflammation.
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LoginThis site does have some good overall info that is not a terribly tough read.
Resveratrol and Pterostilbene. The exact mechanism by which resveratrol exerts anti-inflammatory activity has not been established, although it inhibits a variety of pro-inflammatory compounds (cyclooxygenase, TNF-α, IL-1β, IL-6, NF-κβ) in animal models and human cell culture (Jha et al. 2010; Khanduja et al. 2004). The related compound pterostilbene has demonstrated similar inhibition of inflammatory markers in cell culture (Pan et al. 2008). Modulation of the inflammatory immune response likely contributes to resveratrol’s protective role in animal models of heart disease, cancer, acute pancreatitis and inflammatory bowel disease (Clarke et al. 2008). Resveratrol may be protective against general, low-level para-inflammation as well: when taken with a single high-fat, high-carbohydrate meal (930 kcal), resveratrol (100 mg) prevented the sharp post-meal increases in markers of oxidation and inflammation in a small crossover study of 10 healthy volunteers. For example, synthesis of IL-1β increased by 91% over 5 hours following the test meal; with resveratrol, this increase was significantly less (29%) (Ghanim et al. 2011).Tea polyphenols. The anti-inflammatory effects of green and black tea polyphenols have been substantiated by dozens of in vitro and animal studies (Singh et al. 2010) The polyphenols EGCG and theaflavin exert their anti-inflammatory effects through the inhibition of the NF-κβ signaling pathway, which decreases expression of several inflammatory proteins (lipoxygenase, cycloxygenase TNF-α IL-1β, IL-6, and IL-8) in cell culture experiments (de Mejia et al. 2009). EGCG also inhibits the production and release of histamine, a key mediator of allergic and inflammatory response, in vitro (Melgarejo et al. 2010). In observational studies of tea consumption, >2 cups of tea/day (black or green) was associated with a nearly 20% reduction in CRP compared to non-tea drinkers, and significantly lower levels of two other inflammatory markers (serum amyloid A and haptogen, which are elevated in coronary heart disease) (De Bacquer et al. 2006). In clinical interventions, black tea appears to be more successful in reducing inflammatory markers than green (Galland 2010). A 25% reduction in CRP was also observed in a small trial of healthy, non-smoking men consuming a black tea extract (equivalent to 4 cups of tea/day) for 6 weeks (Steptoe et al. 2007). A similar average reduction was observed in a larger study of healthy, individuals at high risk for coronary heart disease, but revealed a more dramatic 40-50% reduction in CRP amongst individuals with the highest starting CRP values (>3 mg/L) (Bahorun et al. 2010).There are flavinoids in the berry base which are claimed to be of general good effect and some are not well understood.
The hyaluronic acid is a compound found naturally in the body. It is said to act as a lubricant and a cushion within joints. Also found within the eye.
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LoginMETHYLSULFONYLMETHANE (MSM) is also a metabolite of DMSO. There are claimed uses for it, but I don't know how much is actively supported.
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LoginOverall I would not flag anything I see as overly harmful and at least it seems to be a well thought out formula rather than something conjured out of thin air. I don't have a clue how well it would work, but it seems to me there could be some potential to it.
