vitamin d/ibuprofen treatment

[artworks4]

Thanks for that reply, bj.

Art

[AnitaG]

As you know we slightly differ on dosage..i think for many of us with p, from supplement alone, optimum is around 1000-2000iu maybe 3000iu of D in the winter then that considered for anti cancer, etc 4000-5000iu ...i believe its due to this ll37 cytokine which some of us have an abundance of...and which can increase with too much d resulting in increased redness. so i think its fairly individual..it seems to me, too much D yields more redness, less D...more whitish dustings but less redness so D seems to exert control on skin turnover, but too much adds to redness at some trigger point,  increasing this ll37 inflammatory cytokine and TH17 You are not allowed to view links. Register or Login
perhaps a protein CCR6.. You are not allowed to view links. Register or Login at least thats my grasp of it

Do you think thats why we need the ibu and why most of us dont get good results without it?  I really notice the redness if i miss my ibu..

i think magnesium is pretty common if we eat a normal diet, You are not allowed to view links. Register or Login

oatmeal which is a morning staple for me is full of it..as are many foods..so i don't those who eat well are low and in addition, the formula includes a multivitamin precisely to fill the gaps in some small way.
I don't know how low magnesium interferes with D..perhaps in absorption... As we age its commonly accepted there is a deterioration in the GI tract, bile production etc.. the segmented(SFB) bacteria we have talked about producing th17(and why we try the yogurt), there probably is lower absorption as we age...

bj

I've noticed before that my diet is extremely high in magnesium.. if theres a link between it and Vit D then that could explain my good results

[bjm]

hi anitaG...i agree, the ibu is important to get some control on this...its damn complicated as ibu does many things..many of them positive and a few negatives..which is why we limit the dosage...i think it does interfere with the ll37 peptide and mRNA coding for TNF-a..as well as reducing inflammatory prostaglandins etc..which are involved in our P..

now i found one reference to p being exacerbated by ibuprofen..so its possible..
You are not allowed to view links. Register or Login perhaps with adequate D this could  have been reduced...

but then there are always exceptions as  biologics can also exacerbate psoriasis
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here's a new article on B vitamins and getting old... 
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note the higher doses of b12 and folic acid in the formula...i take 500mcg of b12 as i am over 55 and 800mcg of folic when in the sun 400mcg when not...,both might help those who are older (although high folic acid has been implicated in some increase in colon cancer for those who may have a precancerous lesion..the good amount of D we take may attenuate this)..according to the article at 60 and over  i am losing .5% of my brain yearly?......i think more as my short term memory has deteriorated

relating to us with p..another form of inflammation...VEGF(angiogenesis or blood vessel formation) and mRNA expression in leukocytes is reduced by lowering the homocysteine levels with b12,folate.... so adequate b vitamins are important and doubly so if older with P


how long is a year anyway?..

[floss]

Hi bj, thought I would give you an update, things went from bad to worse and I was admitted to hospital, nothing much happened but I think the rest did some good, yesterday I got my first Humira injection, have resigned myself to it and maybe the formula will still work alongside it ( I have never stopped taking it), and amazing my skin is improved in the last week, just with the good sunshine we have been having.
I found those last articles very interesting and will be keeping check on what you come up with next.
Regards, Floss

[bjm]

hi floss...good to hear you are on the mend..started the humira yesterday i see...sounds good!...anything to keep the inflammation in check has to be celebrated...i see that bit of sun helped you back in march also.... as it appears to now..but not enough as i have watched you struggle with this....lets hope a good consistent remission is in the wind.....might think about that yogurt down the road..

looking back through your posts, i think you agree, too much D for too long can increase inflammation..and if there is a GI issue, lack of sun, that adds to the problem...

 as far as new ideas... ...the well is running dry if i am to believe the previous post on getting old...Thanks to Art and chaps they gave me the idea on the GI bacteria and th17 as a source of inflammation.. and it follows that lactobacillius yogurt may be effective in controlling that bug..i think it can if in sufficient quantity and a decent prebionic diet...apples in my case... 

knowing that you will do well...fingers crossed..

bj

[carter90cmc]

will this work with just 1000iu of vd3

because i dont get enough sun and when im in the sun its seems like my p gets better.

could i have a deficiency in vd3

[bjm]

hi carter...if you don't get much sun you probably have a deficiency of D...1000iu is a good start...AnitaG had good results with the D and ibuprofen and a good diet...it is such a multi faceted complex disease, it may take more then one addition or supplement and even then some sun or light can be a big help...

here's the recipe..

1000-2000iu of vitamin D, with a meal
a small multivitamin  (to fill any gaps)
200-500mcg of b12 if over 50-55
400mcg folic acid if in the sun or uvb/uva/nbuvb light

one 200mg ibuprofen in the evening, two 200mg  for shorter duration if there is flairing  Remember not for those trying to get pregnant, pregnant or people with asthma especially children

some sun, light, uvb/uva , tanning  or narrowband can really help to jump start things

1-2 cups/day of homemade yogurt, perhaps more if its commercial yogurt

and/or.....50-200mg enteric coated peppermint oil 2-3 times a day and/or peppermint altoids randomly..about 15/day


optional ..fish or flax oil and selenium

a moderate diet...go lighter on gluten, bread, tomatoes, legumes, beans peanuts until the yogurt appears to help.....one week to a month...

bj

[wexfordfox]

Hi all,

First post here.

Kudos to Bjm, the Dalai Lama of psoriasis sufferers the world over (or this forum anyway).

Have had the P for about three years now.

My first hint of cure back in Jan was here:
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I still do the juicing occasionally (was much more assiduous before the sun became a factor) and will probably get back into it as the sun weakens.

Second hint was this thread back in March and since then baking in the sun from April in the UK in tandem with the Vit D and magnesium (read somewhere that Vit D has a synergistic relationship with magnesium - true for me) thanks to Bjm have got my regular life back.

Never quite cleared but only have the odd non-itchy mildly pink patches (less than 5% coverage) versus (about 25% coverage) bright red itchy as **** patches back in December 2009. Haven't tried the yoghurt or ibu yet - will do in the winter if the P gets worse again (kind of expect this now that the UK sun is losing its power but you never know). So long as I avoid the tomatoes and beers (wine seems to be fine - thank heavens for that) no flares.

So thanks you Bjm - you've given me a handle on the P - one of the greatest gifts I've been given in life.

Without wishing to offend anybody and as stated by many before resolving the P is a personal journey where you've got to do your own experimentation etc. Just my opinion but asking Bjm is this OK, is that OK you may be missing the point.

Just my two cents.

Good luck in your search for control/cure for the P,
Steve

[bjm]

hi steve..thanks...glad its helped you as it has me...

We are all sharing what might help and what doesn't, ideas on why, our common experiences and scientific links can benefit many...i get a lot of insight into my own psoriasis from the rest of you,  so thanks from me.

bj

[wexfordfox]

Agreed Bjm,

You can't beat the collaborative effort. If only docs/derms had the time/inclination to hook into this. That's be a world of pain removed for so many.

As a scientist I don't accept everything I read in the literature (especially newspapers) but I do read it and think about it. Feynman is a good source for why most scientist's are lazy and a bit rubbish and can't see the wood for the trees (definitely the case with psoriasis). That said your links are always worth reading - I just wish I could read more than the extracts at pubmed....

FWIW my regime is based on Vit. D (this appears to have had the most impact but only since alkalizing the body); alakalizing the body (this also appear very much to have helped) and tending to a non-inflammatory pro-Omega 3 diet (also helpful).

My regime (in order of what I think has helped):
- Vit D: 1000 IU daily with  a week off here and there (pretty sure it helps non-scalp skin). Open to trying more in the winter should P worsen.
- Steam room: 15+ minutes post-showering (once a week summer - 3 times a week winter). Sweat out the toxins. Skin patches brush off easily. Apply olive oil over limbs after drying. wrt olive oil: if you wouldn't eat don't put it on your skin.
- Washing: Avoid soap/shampoo with Sodium Laureate Sulphate or such-like. This had an instant (as in within days) impact.
Avoid (this is very much personal): Tomatoes, dairy, beer, coffee and limit black tea in that order. Have considered giving up wheat but impact of the rest of this list makes me go: Nah.
- Smoothies: Apple, carrot, beetroot and celery smoothies (weekly in summer; bi-daily in winter). Nutritious + anti-inflammatory + alkalizing affect on body.
- Gimchee: Irregular but at least weekly. This is home made Korean fermeted cabbage/cucumber/etc. not too different from German Saurkraut I guess. This is possibly my yoghurt substitute.
- Fish (usually sardines): Approximately three times a week with dinner plus (soft-gel) omega 3 1g capsule after lunch.
- Exercise: 2x30 mins cycle 5 times a week.
- Drinks: Large glass of water with half squeezed lemon on waking. Mineral water - approx 2L a day. Alakalizing.
- Magnesium: 100mg Mg Citrate daily plus plenty of good food sources (home-ground flax seed etc.). Works with Vit D. Also has alakalizing effect on body.
- Other food: Am Irish so have replaced the humble spud with sweet potatoe, rice, buckwheat and millet to good effect.
- Multi-vit: Centrum Performance 3-4 times a week
- Meat: Much more chicken. Much less beef and pork. Same amount of lamb. No processed meats/fish.
- Lecithin: Teaspoon with breakfast. Supposed to help absorb fats but suspect it's irrlevant. Alkalizing.
- IBU: None yet.

hth someone,
Steve