vitamin d/ibuprofen treatment

[Eveloftus]

Yeah Jay I agree low carbs is great for losing weight! (I think it also helps my PA but not sure about the effect on my skin though)

 

[Spotted_owl]

I was just reading this study and found it very interesting and unusual. I don't think I've ever seen one quite like it.
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Some of what I found interesting was the fact that these researchers achieved results that are as good or better than the available pharmaceuticals for psoriasis by using herbs. The length and size of the study was also impressive.
Also interesting was the observed difference in response in people who had previously been treated with immune suppressant therapy compared to those who hadn't.
Another unusuall aspect was the worsening of psoriasis in the fist months of treatment. In the accompanying 2nd and 3rd stage photos, the psoriasis looks considerably worse than in the starting photos.........enough so to make you think that most patients would have dropped out of the treatment study, but quite a few stuck it out and obtained very good results over time.

Art

Hey Art, thanks for posting this.  I find it very interesting as well.  It echoes my concern about most standard immune suppressing therapies.

Also what I found interesting was this:
During the study, we also observed that visible recovery began form head region downwards gradually spreading towards lower limbs in all responded patients with prior non-immunosuppressants therapy, complete clearance was within 8 months (Figure 2), when existing psoriatic plaques were eradicated, the subsided lesion areas became paler than normal skin color similar to vitiligo (Figure 5) compared to the normal surrounding skin, and the skin areas with vitiligo coloration evolved to a natural skin tone within three months without further medication.

I achieved my clearing with omega 3,6,9 and evening primrose oil and milk thistle.  Well over half of my outbreak was erythro type and it cleared from chest level (armpit level all the way around my trunk) down to my waist, down my thighs to my knees and the last to clear was actually the tops of my feet.  From my knees down, my skin is still mottled and a different color than the unaffected areas, but it is slowly fading back to normal.

The only other thing I can say is that my clearance was faster, it only took two months, but then I think that happened because I was only six weeks into my severe outbreak, so I don't think that my psoriasis had time to really "set in" hard.  Incidentally, the areas where I have long had minor outbreaks still have not totally cleared, although they remain very minor in nature.

I am very glad to see studies that do a decent job of supporting the alternative approach to dealing with psoriasis.  And this one looks to be a beaut.  I firmly believe there is benefit in this approach.

[artworks4]

Spotted owl,

Yes, I agree........the difference in how the immune suppressed treated group cleared compared to the non immune suppressive  group really was quite interesting and I can't remember ever seeing a study which brought this subject up  before, but it is nice to see! Now if they can just figure out what are the most effective ingredients in that combination and why, that would be really great!

Art

[scratchydude]

also i would not take any C or rose hips until i had a remission..i go back to that th1/th2 hypothesis and vitamin C pushing thelper cells toward th1 and more psoriasis..it may or not be true..but you don't have time to find out...so i would keep it simple, D, GS, diet...might try curcumin as art suggests...but i would not make it too complicated...i would be rigid on that diet...no flour or grain products

then i would  eliminate all gluten, bread etc, corn, any grains..more salads, no citrus, no tomatoes, beans less or no potatoes.  Meat, fish, rice, salad not a problem, some probiotics,,yogurt or capsules.. you should see some reduction in inflammation in a week or two..at least try for month and then sparingly until remission if there is one in the cards..

With the exception of his Vitamin C suggestions (he isn't considering P but inflammation in general), i would follow these recommendations by a molecular biologist
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note...until there is control or remission, the only advantage of higher dosages of vitamin C  >500mg that i can see  is to help relieve the symptoms of gout(reducing uric acid levels) which can also exacerbate p and in that case i have used it in the short run as well as during summer sun ...

Hi Bj,

I do not want to be out of topic here, but while digging into a new alternative treatment (the blood type diet) I found something interesting related to what you're saying above:

"Psoriasis is caused genetically, but provoked largely by cellular changes resulting from the expression of toxins called polyamines. Lectins also stimulate polyamine formation, as they stimulate cells on the inestinal wall to secrete more protein, which give the colon bacteria more material to convert into polyamines (a very nice foward and reverse association, no?) Many dietary lectins are blood type specific.

These chemicals (polyamines) result from ineffectual digestion and subsequent bacterial putrefaction of proteins, principally tryptophane. Polyamines stimulate among other things a chemical cascade called complement (also stimulated by lectins). Complement can cause a burst in intracellular energy compounds, cGMP and cAMP, which are the driving force in the high metabolic rate of psoriatic skin cells. This is a prime reason to not overdose on vitamin C if you have the condition, as ascorbate also does this.

Both polyamine formation and lectin avoidance are addressed in ER4YT, which is probably why the diet does work rather well in psoriasis."

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[beat-the-p]

Hi Art

I still have some curcumin c3 complex left so I will get back on that.. im trying to remember what helped last time and I definitely taking that so thanks for the reminder.. I read up loads on curc hence why i paid for the best stuff.

BJ thanks again for your advice.. I may be tempted to buy the glucosamine so thanks for that suggestion as well. I think you are right keep it fairly simple.. all I know last time was then I was on d3 curc c3 complex, rosehip tabs, pomegranate tabs, b12 in large amounts and also a zinc/magnesium/calcium (all combined) tab. I took this combination every day for months so I will get back on that I think as it either helped before or was just luck. I never took ibu then recently i have been taking a lot because of the inflammation in my knee but it doesn’t touch it one bit. I know about the risk of ulcer.. Bleeding etc.. with large doses, so with no useful effect on my arthritis I will reserve it for headaches that I am getting fairly regularly at the moment.. prob due to some referred neck pain.. I am not dehydrated as I get through 4-6 pints of fresh water a day. I think the ibu gel may be useful for pain but is useless when you have the level of inflammation I do.. not even a cortisone injection with aspiration can control it for more than a few days and I can't keep getting them at my age. I fear the drugs will be the only option now.. but I have till April 30th.. so will see between now and then.

Thanks for all the advice and suggestions guys

Best regards, btp

[artworks4]

Hi Art

I still have some curcumin c3 complex left so I will get back on that.. im trying to remember what helped last time and I definitely taking that so thanks for the reminder.. I read up loads on curc hence why i paid for the best stuff.

BJ thanks again for your advice.. I may be tempted to buy the glucosamine so thanks for that suggestion as well. I think you are right keep it fairly simple.. all I know last time was then I was on d3 curc c3 complex, rosehip tabs, pomegranate tabs, b12 in large amounts and also a zinc/magnesium/calcium (all combined) tab. I took this combination every day for months so I will get back on that I think as it either helped before or was just luck. I never took ibu then recently i have been taking a lot because of the inflammation in my knee but it doesn’t touch it one bit. I know about the risk of ulcer.. Bleeding etc.. with large doses, so with no useful effect on my arthritis I will reserve it for headaches that I am getting fairly regularly at the moment.. prob due to some referred neck pain.. I am not dehydrated as I get through 4-6 pints of fresh water a day. I think the ibu gel may be useful for pain but is useless when you have the level of inflammation I do.. not even a cortisone injection with aspiration can control it for more than a few days and I can't keep getting them at my age. I fear the drugs will be the only option now.. but I have till April 30th.. so will see between now and then.

Thanks for all the advice and suggestions guys

Best regards, btp

btp, It's been quite awhile since I took curcumin, so my recollection may be off, but it seems like it took a few days to two weeks to notice a very significant reduction in pain. Not having kept a diary, it just seems like it was a fairly quick response so it shouldn't take you too long to find out if that is part of what helped you last time.
Yes, the studies are very enticing and mainly what lead me to try it in the first place and the studies since, continue to be enticing.........I wish I could take it again.

Art

[elgrande]

What is in the small multi you take BJ? Does it include minerals etc as well? Thanks

[bjm]

hi el...for the multivitamin i just use a generic vitamin mineral combo from walmart..called equate multivitamin/mineral for men   i see it has some selenium in it 100mcg..some lycopene, a little zinc and other minerals, some calcium...and the rest ..the B's, A , C etc....not too special...but it might fill any gaps in diet (if i am eating well, i often skip it)

  plus i take the 4000iu of D, 2000mg of glucosamine sulphate, ibu,  b12,..no grains, low sugar, (i use aspertame),more salads, daily yogurt, some peppermint and (recently)a majority of calories from fats (meat,fish) and low carbs, exercise ...and always, quite a bit of coffee and green tea....seems to  be working well considering the time of year..

so for me, its getting the psoriasis specific tcell and helper tcell counts lower with sun (others might use light), then try to keep them low and controlled (fall winter)by maintaining an anti inflammatory lifestyle which includes some vitamins etc, diet changes, and dealing with any inflammation..teeth and gums, gi tract, infection etc....Although i think especially with psoriasis, getting  any inflammation under control can help with most health issues...as aging and inflammation are almost synonymous

its kind of like juggling..but it works for me.

[bjm]

I do not want to be out of topic here, but while digging into a new alternative treatment (the blood type diet) I found something interesting related to what you're saying above:

hi scratch..no, its never off topic..i think anyone is welcome to voice their ideas in any thread....that's the beauty of this forum

yes, it looks similar alright...i look at the literature and with so many variables, so many unknowns, complex interactions etc..its hard to decipher it all...
finally i resort to a quasi black box method..., i see something in the literature, or some others experience that might have merit..try it, see if a get a response (which is rare) and if i do, see how it might fit..if not i move on and try something else..its a slow prodding process but it can bring benefits...two steps forward..then one back 

[igH]

hi bjm, but nsaid's also cause inflammation in the gut + increase intestinal permeability... have you considered glutamine?