vitamin d/ibuprofen treatment

[bjm]

hi Art..i don't know much about Excema....i do know that they get skin infections where as usually we don't. This is in part because while we have more of the LL37 wound healing peptide  in our lesions then a normal person...they have less less of the peptide and hence increased infection....kind of the opposite of us..

probably the additional vitamin D alone with help with skin infections etc...i'll read about it....its an interesting subject...and ya, its tough when kids are sick....

hi Radar...someone will pop in to let your know the best deal..

survivor night..a new one is just beginning...

bj

[joedoe]

getting my d3 of ebay from a to z natural health good price and speedy delivery
they go under the name of a2znh i anyone is interested

[totoro]

getting my d3 of ebay from a to z natural health good price and speedy delivery
they go under the name of a2znh i anyone is interested

Me too, they are good ebayers, good value and speedy delivery.
Some question the quality of VitD3 brought off of ebay but I can confirm
that the majority of Vit D3 that I and a friend have been using since May 09
has come from ebay sellers and these ones mostly.

There are plenty of other places on line to get it too, and why Holland & Barrett
 and Boots dont realise that Vit D3 is product worth stocking I have no idea.

Yes they both sell it, but in a small iu and so far I havent found the gel capsule
version in either. ( But I havent looked in the last few weeks).

T

[Eveloftus]

Hi everybody, Dottie posted this very interesting article on lectins, on the US forum: I was particularly interested in teh fact that infections strip away protection from lectins by sialic acid molecules on the cells of the gastro intestinal mucosa, thus exposing them to the harmful effect of lectins, and maybe that's why P often is triggered by an infection.




Do dietary lectins cause disease?
The evidence is suggestiveand raises interesting possibilities for treatment



In 1988 a hospital launched a "healthy eating day" in its staff canteen at lunchtime. One dish contained red kidney beans, and 31 portions were served. At 3 pm one of the customers, a surgical registrar, vomited in theatre. Over the next four hours 10 more customers suffered profuse vomiting, some with diarrhoea. All had recovered by next day. No pathogens were isolated from the food, but the beans contained an abnormally high concentration of the lectin phytohaemagglutinin.1 Lectins are carbohydrate binding proteins present in most plants, especially seeds and tubers like cereals, potatoes, and beans. Until recently their main use was as histology and blood transfusion reagents, but in the past two decades we have realised that many lectins are (a) toxic, inflammatory, or both; (b) resistant to cooking and digestive enzymes; and (c) present in much of our food.2 It is thus no surprise that they sometimes cause "food poisoning." But the really disturbing finding came with the discovery in 1989 that some food lectins get past the gut wall and deposit themselves in distant organs. 3 4 So do they cause real life diseases?

This is no academic question because diet is one part of the environment that is manipulable and because lectins have excellent antidotes, at least in vitro. Because of their precise carbohydrate specificities, lectins can be blocked by simple sugars and oligosaccharides. Wheat lectin, for example, is blocked by the sugar N-acetyl glucosamine and its polymers.5 These natural compounds are potentially exploitable as drugs should lectin induced diseases be identified.

Wheat gliadin, which causes coeliac disease, contains a lectin like substance that binds to human intestinal mucosa,6 and this has been debated as the "coeliac disease toxin" for over 20 years.7 But coeliac disease is already managed by gluten avoidance, so nothing would change were the lectin hypothesis proved. On the other hand, wheat lectin also binds to glomerular capillary walls, mesangial cells, and tubules of human kidney and (in rodents) binds IgA and induces IgA mesangial deposits. This suggests that in humans IgA nephropathy might be caused or aggravated by wheat lectin; indeed a trial of gluten avoidance in children with this disease reported reduced proteinuria and immune complex levels.8

Of particular interest is the implication for autoimmune diseases. Lectins stimulate class II HLA antigens on cells that do not normally display them, such as pancreatic islet and thyroid cells.9 The islet cell determinant to which cytotoxic autoantibodies bind in insulin dependent diabetes mellitus is the disaccharide N-acetyl lactosamine,10 which must bind tomato lectin if present and probably also the lectins of wheat, potato, and peanuts. This would result in islet cells expressing both class II HLA antigens and foreign antigen togethera sitting duck for autoimmune attack. Certain foods (wheat, soya) are indeed diabetogenic in genetically susceptible mice.11 Insulin dependent diabetes therefore is another potential lectin disease and could possibly be prevented by prophylactic oligosaccharides.

Another suspect lectin disease is rheumatoid arthritis. The normal human IgG molecule possesses carbohydrate side chains, which terminate with galactose. In rheumatoid arthritis much of the galactose is missing, so that the subterminal sugarN-acetyl glucosamineis exposed instead. These deficient IgG molecules feature strongly in the circulating immune complexes that cause fever and symptoms.12 In diet responsive rheumatoid arthritis one of the commonest trigger foods is wheat, and wheat lectin is specific for N-acetyl glucosaminethe sugar that is normally hidden but exposed in rheumatoid arthritis. This suggests that N-acetyl glucosamine oligomers such as chitotetraose (derived from the chitin that forms crustacean shells) might be an effective treatment for diet associated rheumatoid arthritis. Interestingly, the health food trade has already siezed on N-acetyl glucosamine as an antiarthritic supplement.

SEE NEXT POST FOR REST OF ARTICLE

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[Eveloftus]

REST OF ARTICLE

Among the effects observed in the small intestine of lectin fed rodents is stripping away of the mucous coat to expose naked mucosa and overgrowth of the mucosa by abnormal bacteria and protozoa.14 Lectins also cause discharge of histamine from gastric mast cells,15 which stimulates acid secretion. So the three main pathogenic factors for peptic ulceracid stimulation, failure of the mucous defence layer, and abnormal bacterial proliferation (Helicobacter pylori) are all theoretically linked to lectins. If true, blocking these effects by oligosaccharides would represent an attractive and more physiological treatment for peptic ulcer than suppressing stomach acid. The mucus stripping effect of lectins16 also offers an explanation for the anecdotal finding of many allergists that a "stone age diet," which eliminates most starchy foods and therefore most lectins, protects against common upper respiratory viral infections: without lectins in the throat the nasopharyngeal mucus lining would be more effective as a barrier to viruses.

But if we all eat lectins, why don't we all get insulin dependent diabetes, rheumatoid arthritis, IgA nephropathy, and peptic ulcers? Partly because of biological variation in the glycoconjugates that coat our cells and partly because these are protected behind a fine screen of sialic acid molecules, attached to the glycoprotein tips.10 We should be safe. But the sialic acid molecules can be stripped off by the enzyme neuraminidase, present in several micro-organisms such as influenzaviruses and streptococci. This may explain why diabetes and rheumatoid arthritis tend to occur as sequelae of infections. This facilitation of lectins by micro-organisms throws a new light on postinfectious diseases and makes the folklore cure of fasting during a fever seem sensible.

Alternative medicine popularisers are already publishing articles about dietary lectins,17 often with more enthusiasm than caution, so patients are starting to ask about them and doctors need to be armed with facts. The same comment applies to entrepreneurs at the opposite end of the commercial spectrum. Many lectins are powerful allergens, and prohevein, the principal allergen of rubber latex, is one. It has been engineered into transgenic tomatoes for its fungistatic properties,18 so we can expect an outbreak of tomato allergy in the near future among latex sensitive individuals. Dr Arpad Pusztai lost his job for publicising concerns of this type (20 February, p 483).

David L J Freed, Allergist. 

14 Marston Road, Salford M7 4ER





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Gilbert RJ. Healthy eating day. Communicable Disease Report 1988; 33: 3-4.
Van Damme EJM, Peumans WJ, Pusztai A, Bardocz S. Handbook of plant lectins: properties and biomedical applications. London: Wiley, 1998:31-50.
Pusztai A, Greer F, Grant G. Specific uptake of dietary lectins into the systemic circulation of rats. Biochem Soc Trans 1989; 17: 481-482.
Wang Q, Yu L-G, Campbell BJ, Milton J, Rhodes JM. Identification of intact peanut lectinin peripheral venous blood. Lancet 1998; 352: 1831-1832[Medline].
Goldstein IJ, Poretz RD. Isolation and chemical properties of lectins. In: Liener IE, Sharon N, Goldstein IJ, eds. The lectins. Orlando: Academic Press , 1986.
Kolberg J, Sollid L. Lectin activity of gluten identified as wheat germ agglutinin. Biochem Biophys Res Comm 1985; 130: 867-872[Medline].
Weiser MM, Douglas AP. An alternative mechanism for gluten toxicity in coeliac disease. Lancet 1976; i: 567.
Coppo R, Amore A, Roccatello D. Dietary antigens and primary IgA nephropathy

[artworks4]

I wonder if other oils can be as effective  or more effective than peppermint oil is for p and IBS? This study gives food for thought on that subject.

Art

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[pedro59]

Hi bj,

I was wondering if you have any idea if BF would be helpful for eczema? I realize that they are two very different diseases, but I notice that eczema can be responsive to uvb treatment like p .

Thank You.

Art

Eczema is usually driven by allergies as opposed to Psoriasis. IGE or immediate reaction allergies as opposed to IGG or delayed alllergies..

The most common allergens implicated with the various forms of Dermatitris (eczema) are inhalents (70% )  and Foods 20 % and the contact allergies 5% and Drug allergies5%..

so an allergy test for the common inhalents (in order ....Dust mites, Grasses, Animal dander, Trees, Mould) and foods (Wheat,Dairy,Nuts, Seafood, Soy) would be very helpful ...

Dustmites can be avoided by covers and using Eucalypt aerosol spray (lethal to dust mites)..

Importantly one tends to keep the IGE type allergy for life but not necessarily the manifestation of the allergy depending on how "maxed out" your immune system is on other known initiating and exacerbating triggers of dermatitis such as chemicals, Stress (read Cortisol levels) ,hormone changes, yeast (Sebhorrheic Dermatitis)and Histamine content of food.Even dehydration does not allow your skin's inbuilt immune sytem to work properly.

IF you have Eczema/Dermatitis AND you have ever had 'hayfever' or asthma..it is even more probable that an allergy is driving your Eczema/dermatitis.

Eczema, hayfever and asthma are a result of Histamine being released by mast cells in the corresponding Skin, Nasal Pharanx or lungs by the Mast Cells in the Skin in response to IGE immunoglobins that are formed in response to these allergens.
Modern RAST IGE serum testing can pinpoint these allegens scientifically.

Psoriasis is not usually IGE mediated (ie to do with allergies) ...BUT..it is possible via the koebner syndrome for an allergic reaction to irritate and make worse Psoriasis.

[bjm]

An interesting blurb i ran across on selenium reducing the risk of the two most common forms of skin cancer....i believe the dosages were 200mcg...i'll try to find the actual study, numbers etc..

but this one quote " Relatively high serum selenium concentrations are associated with an approximately 60 per cent decrease in subsequent tumour incidence of both BCC and SCC,” (basal and squamous cell carcinoma)

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considering many soils are low in selenium  and the UK is included in that group...and with the addition that many are on a low or no gluten diet..flour being a major source of selenium..., and or eat little meat, meat also being a major source.....there aren't many good options to get selenium or then the proverbial Brazil nuts...but they may be too high a dosage  taken daily....as levels over 400mcg  can be getting some toxicity...some can't even take the lower amounts..with reports of legs cramps at even 200mcg...I have been taking 200mcg for 6 years now...with no observed ill effect...there have been several studies of selenium with vitamin E..some concluded no effect, others conclude anti cancer effects..so its still an unknown if a supplement helps in that regard..but we can probably believe that low levels don't help our P...

As shown in this sampling..there about 5 pages of fish or meat as sources..but after that its pretty low..we need about 70mcg/day
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[Sue]

Hi Bj - quick question - how important is it to have the D3 in a softgel capsule?  I have been taking the hard ones - Solgar

[bjm]

hi Sue...good question...in all the studies i've read including Vieth's 1999 study on D, dosage and safety...no mention was made on the form..hard pill or soft gel...in interveiews later Vieth only says it has to be taken with a meal which includes fat or oil to be absorbed properly..as bile is needed to break it down .. and we produce bile when we eat fat or oil...

conversely, this cardiologist claims it has to be the softgel... You are not allowed to view links. Register or Login

i take both or whatever i have on hand...interesting Vieth made the observation that a supplement if absorbed  properly has to be as effective as the sun in making D as its the only way furred animals and birds get their D... the oils from their fur and feathers react with uvb from the sun, much like our skin..and ingesting the D that way..actually most of the D we take comes from lanoline from wool thats irradiated with uvb...purified and made into a tablet or gelcap..

probably more then you wanted to know...

but thats part of the story anyway.