vitamin d/ibuprofen treatment

[Chappers_27]

OK, thanks.

IN THE MEANTIME...(APOLOGIES IF IVE PUT THIS IN THE WRONG THREAD!!)

I've just found this... Silkis (You are not allowed to view links. Register or Login)

"Silkis ointment contains the active ingredient calcitriol, which is a type of medicine called a vitamin D analogue."

I've never used it, never heard of it and never heard of any else using it. Is it the same as Dovonex?

It does say that "There are currently no other medicines available in the UK that contain calcitriol for treating psoriasis"

[bjm]

hi L...calcitriol is the real thing when it comes to vitamin D...it is the potent steroid that we make in our kidneys and in cells in different organs in minute amounts..its the form of D that is active in the cells and VDR's or receptors and measured in the blood in trillionths of a gram..or picograms/mL

The form of vitamin D in dovonex is an analog of calcitriol (chemically similar) and so they could patent it which is what pharma is after...Cacitriol (unpatentable because it is natural) has been available for those with kidney failure as they make little or none and it plays an important role in calcium levels...in unison with the parathyroids...

Because it is so potent, you have to avoid additional D including sunlight as then calcium levels can get high..but it is effective against P ...in the US a similar topical made with calcitriol goes by the name of Vertical. In the latest literature, we also make some in the skin when in uv light and also with higher circulating levels of D or calcidiol a less active form of Vitamin D by 1000.

note...actually a team of brits discovered it back..i forget...and a few months later, a team of aussie, then a few months later a team of yanks...the last ten years the yanks appear to claim it was them all along...but there is a little thing called the record ..and the brits may end up getting the nobel for it...they better or this game is rigged!!!

bj

[bjm]

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hi L...about calcitriol..


THE "AMERICAN DECADE RULE"One of the most interesting things I learned in Victoria is that scientists from England, Canada, New Zealand, Australia, and the rest of the world, do not understand the "American Decade Rule." The rule clearly states that if a U.S. scientist and a foreign scientist both discover the same thing in the same decade, the American gets total credit for it, even if the foreigner discovered it first.Case in point: the discovery of the potent steroid hormone, activated vitamin D or calcitriol—a discovery so important that it regularly starts rumors of a Nobel Prize. Dr. Holick, Dr. Schnoes, and Dr. DeLuca announced their discovery of calcitriol in April of 1971. A group in England, led by Dr. Lawson and Williams, published the same discovery in Nature, in March of 1971, a month earlier. Members of the same English group, Dr. Fraser and Dr. Kodicek, discovered the kidneys make calcitriol in November of 1970, a full six months earlier. However, both English discoveries were within a decade of the Americans. Therefore, the "American Decade Rule" applies and the Americans get total credit. I was surprised that scientists from the Commonwealth find the rule so hard to understand. 


lets hope they get it straight in Sweden     

[artworks4]

Hi bj,

I got some sun last year, but this year I haven't really gotten any sun to speak of. I haven't even worn shorts this year because of the post inflammatory hyperpigmentation spots on my ankles. They're almost as unsightly as the plaques which they replaced but no more red inflammation, they look more like a bruise. Up to this point the weather has remained cool for us, so I wear a hoody most of the time. This weekend is supposed to be the warmest it has been in awhile so I may start to get some sun soon, but pretty much since last November, I would have to say very little sun and no tanning beds. I was looking at a calcium pill that I take and didn't realize that it too has vitamin d at 800 iu per day. With the 400 iu in my multi, I'm actually taking 9,200 iu per day plus any that I get from what I eat or the milk that I drink, but I don't see any redness.......anywhere. Even my scalp, where I still have p, doesn't have any redspots that I can see. I used to have large red spots in my arm pits(inverse p?) that never flaked, they were just red, but even that has gone away. The area behind my ears still has p and it used to get red when it was bad, but there is no redness there either
 I had a problem when I went up to 12,000iu per day that I thought might be related to the high d , but it wasn't redness.

Art

[bjm]

hi art, i don't know..those are high doses...i'd get a blood test..

as far that hyperpigmentation...you know how vitamin D supplements seem to carry a tan longer in the winter, and makes one tan sooner in the spring..probably some feedback loop...my guess is the supplemental doses you are at may have enhanced the hyperpigmentation..while the sun evens it out..

i have dropped to 1500iu..about 1/6 your dose...amd with a little spring uva sun i can see the few brown spots fading, and reduced ankle redness i had  left over from the lectin experiment  turning to a fine dust and breaking up...

I don't know why the peptide is not a problem for you  or if it even a problem for most...i thought you like coggs may be getting light and that seems to diminish the effect as in case of those high levels with sun...as thats not the case i don't have a clue...but the high D might be adding to hyperpigmentation or brown spots....if it were me, i would drop the D  for awhile and get some sun or light
and see what happens ....of course the only definitive way of knowing your D level is with a blood test...

bj

[avadoro]

Hyperpigmentation may be trigerred by :
1 liver - too high levels of toxins or disease that block detoxification
2 misbalanced thyroid hormones - thyrosine is to be checked ( this also may influence psoriasis )
3. High cortisol ( adrenal ) hormone levels

[chloesmum]

Hi,

This is my first time posting on here. After 7 years of trying various topical treatments with limited results my 10 year old daughter is due to start her first course of PUVA treatment in mid April - after reading this and Nicks thread was considering starting her on a low dose of Vit D3 prior to commencement of her treatment. Cannot find much info regarding D3 supplements in children but what do you think??

The evidence on here looks good ......... and anything I can do to increase her chances of p free skin will be greatly appreciated.

Thanks,

Mandy

[artworks4]

Thanks, bj!

I am thinking about lowering the d also, the main thing holding me back is that I am relatively clear and I am afraid of the p coming back. When it was as bad as it was, I used to think it was just something I was going to have to live with for the rest of my life even though I hated it, but now that I am almost clear, it is a very hard thing to mess with what got me to this point. I'll have to order a d test.

Art

[avadoro]

bj,

I have just read some publications about peppermint oil (  in short You are not allowed to view links. Register or Login )
On the far end of the irritable-bowel-syndrome there is high level of cortisol.
This syndrome causes that  calcium and fatty acids are not properly absorbed in gut and interfere metabolism.

Lowering cortisol or modulation adrenal hormones should help with IBS

check this publication:

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[bjm]

hi mandy....well the national institute suggests the safe upper limit for 1-13 is 2000iu/d......Nick was on 1500iu/day

a couple of articles..You are not allowed to view links. Register or Login

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The Puva is UVA light and makes no vitamin D in the skin...perhaps some minor amount depending on the light source..

So with that in mind if it were summer and your child were outside, they would normally be making 1000-5000iu/day from the sun... so i would agree a supplement of 1000-1500iu might have a good effect much like it did for nick...probably should be on 1000iu/day in the winter anyway...

i would mention it to the doc and lets hope he is up to speed on D and not against anecdotal experiences on the net..I'd also talk to nick...maybe get the name of his doc...drop him a line.. and his suggestions

if it were me..she and you would be on 1000iu/day just for bone density and muscle strength ,weight control and height
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good luck ...bj