The MTX depletes the body's natural folic acid intake, so they can up it to one a day excepting MTX day, when you dont take it at all.
If you are taking simvastatin then you must not take grape juice at all as the enzymes in grape juice will cause havoc when mixed with simvastatin. Grapes are okay to eaten, but not the grape juice as sold in shops.....or as given in some churches as communion.